BDBM751334 (2-(4-(9-benzyl- 6-(1- methyl- cyclopropoxy)- 9H- purin-8-yl)-3- chlorophenoxy) ethyl)-L-proline::US20250195530, Example H12

SMILES CC1(Oc2ncnc3c2nc(-c2ccc(OCCN4CCC[C@H]4C(=O)O)cc2Cl)n3Cc2ccccc2)CC1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 751334   

TargetDNA polymerase theta(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 751334BDBM751334((2-(4-(9-benzyl- 6-(1- methyl- cyclopropoxy)- 9H- ...)
Affinity DataIC50: 6.31nMAssay Description:In the assay, Polθ interacts with the substrates (deoxy thymidine triphosphate (dTTP) (Sigma, product code T0251) and a DNA template with a 17-nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent