BDBM757557 6-(Dimethylamino)-N-((2-methylquinolin-8-yl)sulfonyl)-4-(trifluoromethyl)benzofuran-2-carboxamide::US12357603, Example 196

SMILES Cc1ccc2cccc(S(=O)(=O)NC(=O)c3cc4c(C(F)(F)F)cc(N(C)C)cc4o3)c2n1

InChI Key InChIKey=MQMHBJATRJVBAA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757557   

LigandPNGBDBM757557(6-(Dimethylamino)-N-((2-methylquinolin-8-yl)sulfon...)
Affinity DataIC50: 1.47nMAssay Description:Recombinant human His-tagged Kat6a protein (amino acids 194-810), was purified in-house from Baculovirus-infected insect cells (Sf9). Histone H4 pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/28/2025
Entry Details
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TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM757557(6-(Dimethylamino)-N-((2-methylquinolin-8-yl)sulfon...)
Affinity DataIC50: 1.78nMAssay Description:Kat6b was incubated for 30 mins at 22° C. in the presence of different concentrations of test substances (0 μM, and within the range 0.01-20 μM) in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/28/2025
Entry Details
Go to US Patent