BDBM757869 2-(3-((1S,2R)-1,2-difluoro-1-(4-methyl- 4H-1,2,4-triazol-3-yl)propan-2- yl)phenyl)-6-((3-fluoro-3- methylazetidin-1-yl)methyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 31

SMILES Cn1cnnc1[C@H](F)[C@](C)(F)c1cccc(N2Cc3c(cc(CN4CC(C)(F)C4)cc3C(F)(F)F)C2=O)c1

InChI Key InChIKey=VRVWPFYAEYJLSZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757869   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757869BDBM757869(2-(3-((1S,2R)-1,2-difluoro-1-(4-methyl- 4H-1,2,4-t...)
Affinity DataIC50: 88nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757869BDBM757869(2-(3-((1S,2R)-1,2-difluoro-1-(4-methyl- 4H-1,2,4-t...)
Affinity DataIC50: 130nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent