BDBM757882 (R)-6-(5-azaspiro[2.4]heptan-5- ylmethyl)-2-(6-(isopropylamino)-4-(1- (4-methyl-4H-1,2,4-triazol-3-yl)propan- 2-yl)pyridin-2-yl)-4- (trifluoromethyl)isoindolin-1-one formate::US20250230147, Compound 55

SMILES CC(C)Nc1cc([C@H](C)Cc2nncn2C)cc(N2Cc3c(cc(CN4CCC5(CC5)C4)cc3C(F)(F)F)C2=O)n1

InChI Key InChIKey=DVFHPYNKXBTTIS-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757882   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757882BDBM757882((R)-6-(5-azaspiro[2.4]heptan-5- ylmethyl)-2-(6-(is...)
Affinity DataIC50: 16nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757882BDBM757882((R)-6-(5-azaspiro[2.4]heptan-5- ylmethyl)-2-(6-(is...)
Affinity DataIC50: 26nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent