BDBM757946 6-(5-azaspiro[2.4]heptan-5-ylmethyl)-2- (3-((1S,2R)-1,2-difluoro-1-(4-methyl- 4H-1,2,4-triazol-3-yl)propan-2- yl)phenyl)-4-(trifluoromethyl)isoindolin- 1-one::US20250230147, Compound 127

SMILES Cn1cnnc1[C@H](F)[C@](C)(F)c1cccc(N2Cc3c(cc(CN4CCC5(CC5)C4)cc3C(F)(F)F)C2=O)c1

InChI Key InChIKey=PWYZIGWGQHWCDC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757946   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757946BDBM757946(6-(5-azaspiro[2.4]heptan-5-ylmethyl)-2- (3-((1S,2R...)
Affinity DataIC50: 77nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757946BDBM757946(6-(5-azaspiro[2.4]heptan-5-ylmethyl)-2- (3-((1S,2R...)
Affinity DataIC50: 170nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent