BDBM757949 6-(5-azaspiro[2.4]heptan-5-ylmethyl)-2- (3-((1R,2S)-1,2-difluoro-1-(4-methyl- 4H-1,2,4-triazol-3-yl)propan-2- yl)phenyl)-4-(trifluoromethyl)isoindolin- 1-one::US20250230147, Compound 130

SMILES Cn1cnnc1[C@@H](F)[C@@](C)(F)c1cccc(N2Cc3c(cc(CN4CCC5(CC5)C4)cc3C(F)(F)F)C2=O)c1

InChI Key InChIKey=PWYZIGWGQHWCDC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757949   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757949BDBM757949(6-(5-azaspiro[2.4]heptan-5-ylmethyl)-2- (3-((1R,2S...)
Affinity DataIC50: 4.00E+3nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757949BDBM757949(6-(5-azaspiro[2.4]heptan-5-ylmethyl)-2- (3-((1R,2S...)
Affinity DataIC50: 1.30E+4nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent