BDBM757969 2-(3-(3-((R)-fluoro(4-methyl-4H-1,2,4- triazol-3-yl)methyl)oxetan-3-yl)phenyl)- 6-(((R)-2-(hydroxymethyl)pyrrolidin-1- yl)methyl)-4-(trifluoromethyl)isoindolin- 1-one::US20250230147, Compound 147

SMILES Cn1cnnc1[C@H](F)C1(c2cccc(N3Cc4c(cc(CN5CCC[C@@H]5CO)cc4C(F)(F)F)C3=O)c2)COC1

InChI Key InChIKey=BOXCRIQFGKVQGT-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757969   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757969BDBM757969(2-(3-(3-((R)-fluoro(4-methyl-4H-1,2,4- triazol-3-y...)
Affinity DataIC50: 150nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757969BDBM757969(2-(3-(3-((R)-fluoro(4-methyl-4H-1,2,4- triazol-3-y...)
Affinity DataIC50: 190nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent