BDBM757989 (R)-6-((3-ethyl-3-hydroxyazetidin-1- yl)methyl)-2-(3-(3-(fluoro(4-methyl-4H- 1,2,4-triazol-3-yl)methyl)oxetan-3- yl)phenyl)-4-(trifluoromethyl)isoindolin- 1-one::US20250230147, Compound 167

SMILES CCC1(O)CN(Cc2cc3c(c(C(F)(F)F)c2)CN(c2cccc(C4([C@@H](F)c5nncn5C)COC4)c2)C3=O)C1

InChI Key InChIKey=ATJOFYROOCTSJY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757989   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757989BDBM757989((R)-6-((3-ethyl-3-hydroxyazetidin-1- yl)methyl)-2-...)
Affinity DataIC50: 59nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757989BDBM757989((R)-6-((3-ethyl-3-hydroxyazetidin-1- yl)methyl)-2-...)
Affinity DataIC50: 150nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent