BDBM758014 6-((S)-1-aminoethyl)-2-(3-(3-((R)- fluoro(4-methyl-4H-1,2,4-triazol-3- yl)methyl)oxetan-3-yl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 192

SMILES C[C@H](N)c1cc2c(c(C(F)(F)F)c1)CN(c1cccc(C3([C@@H](F)c4nncn4C)COC3)c1)C2=O

InChI Key InChIKey=NHQLEHSXIHNSGL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758014   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758014BDBM758014(6-((S)-1-aminoethyl)-2-(3-(3-((R)- fluoro(4-methyl...)
Affinity DataIC50: 32nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758014BDBM758014(6-((S)-1-aminoethyl)-2-(3-(3-((R)- fluoro(4-methyl...)
Affinity DataIC50: 53nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent