BDBM758094 (S)-2-(6-(allylamino)-4-(1-((4-methyl- 4H-1,2,4-triazol-3- yl)methyl)cyclobutyl)pyridin-2-yl)-6-((2- isopropyl-4-methylpiperazin-1- yl)methyl)-4-(trifluoromethyl)isoindolin- 1-one::US20250230147, Compound 275

SMILES C=CCNc1cc(C2(Cc3nncn3C)CCC2)cc(N2Cc3c(cc(CN4CCN(C)C[C@@H]4C(C)C)cc3C(F)(F)F)C2=O)n1

InChI Key InChIKey=NQYLCVJGUIAUJB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758094   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM758094((S)-2-(6-(allylamino)-4-(1-((4-methyl- 4H-1,2,4-tr...)
Ligand Info
In Depth
Date in BDB:
10/30/2025
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM758094((S)-2-(6-(allylamino)-4-(1-((4-methyl- 4H-1,2,4-tr...)
Ligand Info
In Depth
Date in BDB:
10/30/2025
Entry Details
Go to US Patent