BDBM758097 2-(6-((cyclopropylmethyl)amino)-4-(1- ((R)-fluoro(4-methy-4H-1,2,4-triazol-3- yl)methyl)cyclobutyl)pyridin-2-yl)-6- (((S)-2-isopropyl-4-methylpiperazin-1- yl)methyl)-4-(trifluoromethyl)isoindolin- 1-one::US20250230147, Compound 278

SMILES CC(C)[C@H]1CN(C)CCN1Cc1cc2c(c(C(F)(F)F)c1)CN(c1cc(C3([C@@H](F)c4nncn4C)CCC3)cc(NCC3CC3)n1)C2=O

InChI Key InChIKey=TWLQCVTUUJDZGU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758097   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758097BDBM758097(2-(6-((cyclopropylmethyl)amino)-4-(1- ((R)-fluoro(...)
Affinity DataIC50: 12nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758097BDBM758097(2-(6-((cyclopropylmethyl)amino)-4-(1- ((R)-fluoro(...)
Affinity DataIC50: 15nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent