BDBM758110 (S)-2-(6-(ethylamino)-4-(3-((4-methyl- 4H-1,2,4-triazol-3-yl)methyl)oxetan-3- yl)pyridin-2-yl)-6-((2-isopropyl-4- methylpiperazin-1-yl)methyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 291

SMILES CCNc1cc(C2(Cc3nncn3C)COC2)cc(N2Cc3c(cc(CN4CCN(C)C[C@@H]4C(C)C)cc3C(F)(F)F)C2=O)n1

InChI Key InChIKey=LCQJFHPSCUYDHB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758110   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758110BDBM758110((S)-2-(6-(ethylamino)-4-(3-((4-methyl- 4H-1,2,4-tr...)
Affinity DataIC50: 8.20nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758110BDBM758110((S)-2-(6-(ethylamino)-4-(3-((4-methyl- 4H-1,2,4-tr...)
Affinity DataIC50: 12nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent