BDBM758198 (S)-N-(6-(6-((2-isopropyl-4- methylpiperazin-1-yl)methyl)-1-oxo-4- (trifluoromethyl)isoindolin-2-yl)-4-(1-((4- methyl-4H-1,2,4-triazol-3- yl)methyl)cyclobutyl)pyridin-2- yl)acrylamide::US20250230147, Compound 379

SMILES C=CC(=O)Nc1cc(C2(Cc3nncn3C)CCC2)cc(N2Cc3c(cc(CN4CCN(C)C[C@@H]4C(C)C)cc3C(F)(F)F)C2=O)n1

InChI Key InChIKey=HAPZBUDFGUEAKG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758198   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758198BDBM758198((S)-N-(6-(6-((2-isopropyl-4- methylpiperazin-1-yl)...)
Affinity DataIC50: 35nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758198BDBM758198((S)-N-(6-(6-((2-isopropyl-4- methylpiperazin-1-yl)...)
Affinity DataIC50: 48nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent