BDBM758217 (S)-6-(azetidin-1-ylmethyl)-2-(3-(3,3- difluoro-1-(fluoro(4-methyl-4H-1,2,4- triazol-3-yl)methyl)cyclobutyl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 398

SMILES Cn1cnnc1[C@@H](F)C1(c2cccc(N3Cc4c(cc(CN5CCC5)cc4C(F)(F)F)C3=O)c2)CC(F)(F)C1

InChI Key InChIKey=LCBSGMIEMZZQOE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758217   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758217BDBM758217((S)-6-(azetidin-1-ylmethyl)-2-(3-(3,3- difluoro-1-...)
Affinity DataIC50: 140nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758217BDBM758217((S)-6-(azetidin-1-ylmethyl)-2-(3-(3,3- difluoro-1-...)
Affinity DataIC50: 180nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent