BDBM758242 (S)-6-cyclopropyl-N-(3-(3,3-difluoro-1- (fluoro(4-methyl-4H-1,2,4-triazol-3- yl)methyl)cyclobutyl)phenyl)-4-((3- (hydroxymethyl)-3-methylazetidin-1- yl)methyl)picolinamide::US20250230147, Compound 423

SMILES Cn1cnnc1[C@@H](F)C1(c2cccc(NC(=O)c3cc(CN4CC(C)(CO)C4)cc(C4CC4)n3)c2)CC(F)(F)C1

InChI Key InChIKey=AYCOKUHCRMIOJQ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758242   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758242BDBM758242((S)-6-cyclopropyl-N-(3-(3,3-difluoro-1- (fluoro(4-...)
Affinity DataIC50: 23nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758242BDBM758242((S)-6-cyclopropyl-N-(3-(3,3-difluoro-1- (fluoro(4-...)
Affinity DataIC50: 23nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent