BDBM758276 6-(((cyclopropylmethyl)amino)methyl)- 2-(3-(ethylamino)-5-(1-((4-methyl-4H- 1,2,4-triazol-3- yl)methyl)cyclobutyl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 457

SMILES CCNc1cc(N2Cc3c(cc(CNCC4CC4)cc3C(F)(F)F)C2=O)cc(C2(Cc3nncn3C)CCC2)c1

InChI Key InChIKey=AQAJLTSHGYLTKB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758276   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758276BDBM758276(6-(((cyclopropylmethyl)amino)methyl)- 2-(3-(ethyla...)
Affinity DataIC50: 12nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758276BDBM758276(6-(((cyclopropylmethyl)amino)methyl)- 2-(3-(ethyla...)
Affinity DataIC50: 17nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent