BDBM758277 2-(3-(ethylamino)-5-(1-((4-methyl-4H- 1,2,4-triazol-3- yl)methyl)cyclobutyl)phenyl)-6- ((propylamino)methyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 458

SMILES CCCNCc1cc2c(c(C(F)(F)F)c1)CN(c1cc(NCC)cc(C3(Cc4nncn4C)CCC3)c1)C2=O

InChI Key InChIKey=WUJKXHCCHHGERI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758277   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758277BDBM758277(2-(3-(ethylamino)-5-(1-((4-methyl-4H- 1,2,4-triazo...)
Affinity DataIC50: 15nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758277BDBM758277(2-(3-(ethylamino)-5-(1-((4-methyl-4H- 1,2,4-triazo...)
Affinity DataIC50: 23nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent