BDBM758280 2-(3-(3,3-difluoro-1-((S)-fluoro(4- methyl-4H-1,2,4-triazol-3- yl)methyl)cyclobutyl)phenyl)-6-(((S)-4- ethyl-2-isopropylpiperazin-1-yl)methyl)- 4-(trifluoromethyl)isoindolin-1-one::US20250230147, Compound 461

SMILES CCN1CCN(Cc2cc3c(c(C(F)(F)F)c2)CN(c2cccc(C4([C@H](F)c5nncn5C)CC(F)(F)C4)c2)C3=O)[C@@H](C(C)C)C1

InChI Key InChIKey=QAHWLVWOWLGRJU-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758280   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758280BDBM758280(2-(3-(3,3-difluoro-1-((S)-fluoro(4- methyl-4H-1,2,...)
Affinity DataIC50: 8.20nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758280BDBM758280(2-(3-(3,3-difluoro-1-((S)-fluoro(4- methyl-4H-1,2,...)
Affinity DataIC50: 9.90nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent