BDBM758304 2-(3-(1-((4-ethyl-4H-1,2,4-triazol-3- yl)fluoromethyl)-3,3- difluorocyclobutyl)phenyl)-6-(((S)-2- isopropyl-4-methylpiperazin-1- yl)methyl)-4-(trifluoromethyl) isoindolin-1-one::US20250230147, Compound 485

SMILES CCn1cnnc1C(F)C1(c2cccc(N3Cc4c(cc(CN5CCN(C)C[C@@H]5C(C)C)cc4C(F)(F)F)C3=O)c2)CC(F)(F)C1

InChI Key InChIKey=FSCVSVWLKBPYJN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758304   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758304BDBM758304(2-(3-(1-((4-ethyl-4H-1,2,4-triazol-3- yl)fluoromet...)
Affinity DataIC50: 29nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 758304BDBM758304(2-(3-(1-((4-ethyl-4H-1,2,4-triazol-3- yl)fluoromet...)
Affinity DataIC50: 31nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent