BDBM783843 3-(3-(4-(cyclo- propanecarbonyl)piperazin- 1-yl)-3-oxopropyl)-8-fluoro- 5-methylisoquinolin-1(2H)-one::US12459899, Example 183

SMILES Cc1ccc(F)c2c(=O)[nH]c(CCC(=O)N3CCN(C(=O)C4CC4)CC3)cc12

InChI Key InChIKey=YNXDEIPARLBLSX-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 783843   

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandChemical structure of BindingDB Monomer ID 783843BDBM783843(3-(3-(4-(cyclo- propanecarbonyl)piperazin- 1-yl)-3...)
Affinity DataIC50: 1nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandChemical structure of BindingDB Monomer ID 783843BDBM783843(3-(3-(4-(cyclo- propanecarbonyl)piperazin- 1-yl)-3...)
Affinity DataIC50: 14.7nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details
US Patent