BDBM783936 8-fluoro-5-methyl-3-(3-(4- (pyrimidin-2-yl)piperazin-1- yl)propyl)isoquinolin-1(2H)- one::US12459899, Example 25

SMILES Cc1ccc(F)c2c(=O)[nH]c(CCCN3CCN(c4ncccn4)CC3)cc12

InChI Key InChIKey=HTOCTFNLFAZGNQ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 783936   

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandChemical structure of BindingDB Monomer ID 783936BDBM783936(8-fluoro-5-methyl-3-(3-(4- (pyrimidin-2-yl)piperaz...)
Affinity DataIC50: 1nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details
US Patent