BDBM784134 7-(3-(4-(2-fluoropyridin-4- yl)piperazin-1-yl)propyl)-1,6- naphthyridin-5(6H)-one::US12459899, Example 227

SMILES O=c1[nH]c(CCCN2CCN(c3ccnc(F)c3)CC2)cc2ncccc12

InChI Key InChIKey=HWCQDTSDELPKAO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 784134   

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandChemical structure of BindingDB Monomer ID 784134BDBM784134(7-(3-(4-(2-fluoropyridin-4- yl)piperazin-1-yl)prop...)
Affinity DataIC50: 1nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details
US Patent