BDBM784142 1''-(3-(5-oxo-5,6-dihydro-1,6- naphthyridin-7-yl)propyl)- 1'',2'',3'',6''-tetrahydro-[2,4''- bipyridine]-5-carbonitrile::US12459899, Example 235

SMILES N#Cc1ccc(C2=CCN(CCCc3cc4ncccc4c(=O)[nH]3)CC2)nc1

InChI Key InChIKey=MOWICTWRJDLPIO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 784142   

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandChemical structure of BindingDB Monomer ID 784142BDBM784142(1'-(3-(5-oxo-5,6-dihydro-1,6- naphthyridin-7-yl)pr...)
Affinity DataIC50: 1nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details
US Patent