BDBM8061 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32::4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl)pyrimidin-2-amine, 4::4-methyl-5-{2-[(3-nitrophenyl)amino]pyrimidin-4-yl}-1,3-thiazol-2-amine::CDK Inhibitor, 1::[4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl](3-nitrophenyl)amine

SMILES Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)N(=O)=O)n1

InChI Key InChIKey=DYTKVFHLKPDNRW-UHFFFAOYSA-N

Data  13 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 8061   

TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi: <1nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  2nM ΔG°:  -12.1kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  4nM ΔG°:  -11.6kcal/molepH: 7.2 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  4.60nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  19nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  20nM ΔG°:  -10.7kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  53nM ΔG°:  -10.1kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  70nM ΔG°:  -9.92kcal/molepH: 7.2 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  73nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  73nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  80nM ΔG°:  -9.84kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi: >1.00E+3nM ΔG°: >-8.32kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi: >1.00E+3nM ΔG°: >-8.32kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed