BDBM8269 2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid::4-arylmaleimide deriv. 6-z::I-5

SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2cccc(Cl)c2)ccc1Cl

InChI Key InChIKey=ONVZFCHLOZUXRP-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 8269   

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50:  76nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50:  76nMAssay Description:Inhibition of human GSK3-betaMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The Rockefeller University

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CDK2/cyclinA at 10 mMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50:  160nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50:  76nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM8269(2-chloro-5-{[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihy...)
Affinity DataIC50:  76nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair