BDBM8327 4-(dimethylamino)-N-{5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl}butanamide::pyrazolopyridazine deriv. 9

SMILES CN(C)CCCC(=O)Nc1n[nH]c2nnc(cc12)-c1ccccc1

InChI Key InChIKey=LDHIZDYQCCLGRS-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8327   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8327(4-(dimethylamino)-N-{5-phenyl-1H-pyrazolo[3,4-c]py...)
Affinity DataKi:  1.70E+3nM ΔG°:  -7.76kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Jordan

Curated by ChEMBL
LigandPNGBDBM8327(4-(dimethylamino)-N-{5-phenyl-1H-pyrazolo[3,4-c]py...)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8327(4-(dimethylamino)-N-{5-phenyl-1H-pyrazolo[3,4-c]py...)
Affinity DataIC50:  22nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed