BDBM8465 (2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylmethyl)sulfonamido]-3-methylbutanamide::BMCL16311 Compound 1a::CGS 27023::CGS 27023A::CHEMBL514138::hydroxamate analogue 1
SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO
InChI Key InChIKey=BSIZUMJRKYHEBR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 178 hits for monomerid = 8465
Affinity DataKi: 1.27nM ΔG°: -12.0kcal/mole IC50: 1.90nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human MMP25 by fluorometric assayMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Human)
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
TargetNeutrophil collagenase(Human)
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP8 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against human matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl)Ala-Arg-NH2 as substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of gelatinase-B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:In vitro inhibitory activity against collagenase-3 (matrix metalloprotease-13).More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of rat matrix metalloprotease 13More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human matrix metalloprotease 9More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Human)
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of neutrophil collagenase (Matrix metalloprotease-8)More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Human)
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Human)
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human Matrix metalloprotease-8More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibitory activity against human Matrix metalloprotease-2More data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant MMP9 expressed in mouse myeloma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human MMP9 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of recombinant human proMMP9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Inhibitory activity against human Matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of MMP9 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)Ala-Arg-NH2 as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMT: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
Affinity DataKd: 7nMAssay Description:Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibitory activity against mouse macrophage metalloelastase (MME) using [3H]elastin as a substrateMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Human)
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
University Hospital of The Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human MMP8 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against Matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13.More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human active MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 flu...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of matrix metalloprotease-9 (MMP-9).More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human Matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of truncated gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human matrix metalloprotease 9More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Inhibition of matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
