BDBM8611 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonitrile::CHEMBL468419::CHEMBL9298::Fadrozole::US9271963, Fadrozole

SMILES N#Cc1ccc(cc1)C1CCCc2cncn12

InChI Key InChIKey=CLPFFLWZZBQMAO-UHFFFAOYSA-N

Data  5 KI  83 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 90 hits for monomerid = 8611   

TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of aromatase (unknown origin) transfected in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.0300nMAssay Description:In vitro inhibition of estrogen production in hamster ovarian tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  0.0500nMAssay Description:Competitive inhibition of human aromatase using dibenzylfluorescein substrate after 10 mins preincubation measured every 10 sec for 5 mins by Michael...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  0.600nMAssay Description:Inhibition constant for human aromatase cytochrome P450 19A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxy-corticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in V79MZh cells using [14C]-11-deoxycorticosterone as substrate by HPTLC/phosphoimaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in V79 MZh cells using [14C]-deoxycorticosterone substrate incubated for 6 hrs by HPTLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZ cells using [3H]-11-deoxycorticosterone as substrate after 1 hr by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of CYP11B2 in human V79MZ cells using [3H]-11-deoxycorticosterone as substrate incubated for 1 hr prior to substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human adrenal corticoid CYP11B2 expressed in chinese hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cells assessed as conversion of [4-14C]-11-deoxycorticosterone substrate by HPTLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  1.5nMAssay Description:Aromatase inhibitor potency as iron-binding-related type II difference spectrumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of aromatase in human placental microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human aromatase using dibenzylfluorescein substrate preincubated for 30 mins measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 5nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2006
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human CYP11B2 expressed in renal leiomyoblastoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of CYP11B1 in human V79MZ cells using [3H]-11-deoxycorticosterone as substrate incubated for 1 hr prior to substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxy-corticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in V79MZh cells using [14C]-11-deoxycorticosterone as substrate by HPTLC/phosphoimaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using [3H]-11-deoxycorticosterone as substrate after 1 hr by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in V79 MZh cells using [14C]-deoxycorticosterone substrate incubated for 6 hrs by HPTLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAromatase(Human)
State University of New York Upstate Medical University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 6.40nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 9nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 9.70nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 9.70nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP11B1 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human adrenal corticoid CYP11B1 expressed in chinese hamster V79 MZh cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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