BDBM9064 2-({[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]amino}methyl)-1H-indene-1,3(2H)-dione::2-({[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]amino}methyl)-2,3-dihydro-1H-indene-1,3-dione::Donepezil-tacrine hybrid 9

SMILES O=C1C(CNCCCCCCNc2c3CCCCc3nc3ccccc23)C(=O)c2ccccc12

InChI Key InChIKey=GWPUVGPUFGNKQZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9064   

TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9064(2-({[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]...)
Affinity DataIC50:  98nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9064(2-({[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]...)
Affinity DataIC50:  504nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed