BDBM92833 Bisanilinopyrimidine, 9f::US9249124, 49

SMILES O=c1[nH]c2ccc(Nc3nccc(Nc4ccccc4Cl)n3)cc2[nH]1

InChI Key InChIKey=IHHQKCHZXRIDLL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 92833   

TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandChemical structure of BindingDB Monomer ID 92833BDBM92833(Bisanilinopyrimidine, 9f | US9249124, 49)
Affinity DataIC50: 316nMAssay Description:In vitro enzyme activity assay using Aurora Kinase A. More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandChemical structure of BindingDB Monomer ID 92833BDBM92833(Bisanilinopyrimidine, 9f | US9249124, 49)
Affinity DataIC50: 316nMpH: 7.4 T: 2°CAssay Description:Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
US Patent

TargetAurora kinase B(Human)
Moffitt Cancer Center

LigandChemical structure of BindingDB Monomer ID 92833BDBM92833(Bisanilinopyrimidine, 9f | US9249124, 49)
Affinity DataIC50: 361nMAssay Description:In vitro enzyme activity assay using Aurora Kinase A. More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Moffitt Cancer Center

LigandChemical structure of BindingDB Monomer ID 92833BDBM92833(Bisanilinopyrimidine, 9f | US9249124, 49)
Affinity DataIC50: 5.50E+3nMT: 2°CAssay Description:Specifically, MDA-MB-468 cells (American Type Culture Collection) were maintained in Dulbecco's modified Eagle's medium (DMEM) plus 10% fetus bovine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details
US Patent