BDBM93428 PHD Inhibitor, 12{2,3,4}::PHD Inhibitor, 12{2,4,4}

SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O

InChI Key InChIKey=MWACGNKXRZWRBM-KAYWLYCHSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 93428   

TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Affinity DataIC50:  86.4nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Affinity DataIC50:  104nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Amgen

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Affinity DataIC50:  13.2nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Amgen

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Affinity DataIC50:  14.6nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Amgen

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Affinity DataIC50:  12.6nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Amgen

LigandPNGBDBM93428(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Affinity DataIC50:  12.9nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed