BDBM96274 5-Aza-2'-deoxycytidine::DECITABINE::MLS001332587::SMR000857076::cid_451668

SMILES Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1

InChI Key InChIKey=XAUDJQYHKZQPEU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 96274   

TargetDNA (cytosine-5)-methyltransferase 1(Human)
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM96274(cid_451668 | SMR000857076 | 5-Aza-2'-deoxycyti...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM96274(cid_451668 | SMR000857076 | 5-Aza-2'-deoxycyti...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2020
Entry Details Article
PubMed
TargetRecBCD enzyme subunit RecD(Escherichia coli (strain K12))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM96274(cid_451668 | SMR000857076 | 5-Aza-2'-deoxycyti...)
Affinity DataIC50: 1.18E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
LigandPNGBDBM96274(cid_451668 | SMR000857076 | 5-Aza-2'-deoxycyti...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM96274(cid_451668 | SMR000857076 | 5-Aza-2'-deoxycyti...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM96274(cid_451668 | SMR000857076 | 5-Aza-2'-deoxycyti...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM96274(cid_451668 | SMR000857076 | 5-Aza-2'-deoxycyti...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed