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Report error Found 73 Enz. Inhib. hit(s) with Target = 'Acid-sensing ion channel 3'
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50287160(2-Phenyl-1H-indole-5-carboxamidine | 2-phenyl-1H-i...)
Affinity DataIC50: 2.77E+6nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250132(CHEMBL4080879)
Affinity DataIC50: 8.91E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342653(6-phenylpyridin-2-amine | CHEMBL1671950)
Affinity DataIC50: 7.63E+5nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250131(CHEMBL190275)
Affinity DataIC50: 7.08E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342652(6-bromo-1,2,3,4-tetrahydroisoquinoline | CHEMBL177...)
Affinity DataIC50: 7.01E+5nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataIC50: 5.13E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342657(4-(1H-imidazol-4-yl)aniline | CHEMBL1770736)
Affinity DataIC50: 4.30E+5nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50295285(Ibufenac | (4-Isobutyl-phenyl)-acetic acid | 2-(4-...)
Affinity DataIC50: 4.17E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50169044((2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid | ...)
Affinity DataIC50: 3.89E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296572(2-(3-fluoro-5-methoxyphenyl)-1H-indole-5-carboximi...)
Affinity DataIC50: 3.74E+5nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342655(2-ethyl-1H-indene | CHEMBL1770734)
Affinity DataIC50: 3.63E+5nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50169047((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
Affinity DataIC50: 3.09E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250130(CHEMBL4083814)
Affinity DataIC50: 3.02E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296568(2-(2,6-dichloropyridin-4-yl)-1H-indole-5-carboximi...)
Affinity DataIC50: 2.91E+5nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50250133(Butibufen)
Affinity DataIC50: 2.88E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296569(2-(3-chloro-5-fluorophenyl)-1H-indole-5-carboximid...)
Affinity DataIC50: 2.78E+5nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296567(2-(3,5-dichloro-4-cyanophenyl)-1H-indole-5-carboxi...)
Affinity DataIC50: 2.72E+5nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50074922(2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid | ...)
Affinity DataIC50: 2.29E+5nMAssay Description:Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50171068((3-Methoxy-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-a...)
Affinity DataIC50: 1.90E+5nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342658((4-(1H-imidazol-4-yl)phenyl)methanamine | CHEMBL17...)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296566(2-(2,3,5-trichlorophenyl)-1H-indole-5-carboximidam...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296565(2-(3,5-dichlorophenyl)-1H-indole-5-carboximidamide...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342654(6-phenylpyrimidin-4-amine | CHEMBL1770733)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296574(2-(3-chloro-5-((phenylamino)methyl)phenyl)-1H-indo...)
Affinity DataIC50: 1.14E+5nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342644(2-((5-methoxy-1H-indol-3-yl)methyl)-6-(3-(trifluor...)
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342656(benzo[b]thiophen-2-ylmethanamine | CHEMBL1770735)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296573(2-(3-amino-5-chlorophenyl)-1H-indole-5-carboximida...)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296575(2-(3-(benzylamino)-5-chlorophenyl)-1H-indole-5-car...)
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296570(2-(3-bromo-5-fluorophenyl)-1H-indole-5-carboximida...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296571(2-(3,5-dibromophenyl)-1H-indole-5-carboximidamide ...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50296576(2-(3-chloro-5-methylphenyl)-1H-indole-5-carboximid...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of ASIC3 by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50348109(CHEMBL1800435)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50348105(CHEMBL1800429)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342663(4-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2-meth...)
Affinity DataIC50: 2.76E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342645(6-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,2,...)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50348110(CHEMBL1800079)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342648(2-methyl-4-(4-(6-methylpyridin-2-ylamino)phenyl)bu...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342646(6-(4-(4-methylpiperazin-1-yl)phenyl)-1,2,3,4-tetra...)
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342640(6-bromo-2-((5-methoxy-1H-indol-3-yl)methyl)-1,2,3,...)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50348108(CHEMBL1800434)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342650(4-amino-N-(4-chlorophenethyl)-2-propylquinoline-6-...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50157090(6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of ASIC3 in rat DRG neuronsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342651(N-(6-methylpyridin-2-yl)furo[2,3-c]pyridin-7-amine...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342643(6-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydrois...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342659(2-phenylpyridin-4-amine | CHEMBL1770738)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50348100(CHEMBL1800332)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50342662(2-phenyl-6-(pyridin-2-ylmethyl)pyridin-4-amine | C...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50348101(CHEMBL1800333)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50348096(CHEMBL1800439)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
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