Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with Target = 'Bcl-2 homologous antagonist/killer'
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303503BDBM50303503(CHEMBL4160782 | US10858316, Compound SF-5-141)
Affinity DataKi:  120nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591668BDBM50591668(CHEMBL5198484)
Affinity DataKi:  153nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31809BDBM31809(Apogossypol derivative, 8k)
Affinity DataIC50: 230nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308110BDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKd:  250nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591663BDBM50591663(CHEMBL5203189)
Affinity DataIC50: 280nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591664BDBM50591664(CHEMBL5182721)
Affinity DataIC50: 620nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50266958BDBM50266958(CHEMBL4077940)
Affinity DataKi:  1.79E+3nMAssay Description:Binding affinity to Bak/Mcl-1 (unknown origin) protein protein interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50303215BDBM50303215(CHEMBL4167501)
Affinity DataKi:  2.90E+3nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308110BDBM50308110((S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi:  6.90E+3nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591666BDBM50591666(CHEMBL5207001)
Affinity DataKi:  7.77E+3nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308111BDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKi:  8.00E+3nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308111BDBM50308111((S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)m...)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50266958BDBM50266958(CHEMBL4077940)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of Bak/Mcl-1 (unknown origin) protein protein interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591662BDBM50591662(CHEMBL5208863)
Affinity DataKi:  1.14E+4nMAssay Description:Binding affinity to Mcl-1/Bak protein protein interaction (unknown origin) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50107130BDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKi:  4.40E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591665BDBM50591665(CHEMBL5181238)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485626BDBM50485626(CHEMBL2089285)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485627BDBM50485627(CHEMBL2089283)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485622BDBM50485622(CHEMBL2089284)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485623BDBM50485623(CHEMBL2089287)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485624BDBM50485624(CHEMBL2089292)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485625BDBM50485625(CHEMBL2089288)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485619BDBM50485619(CHEMBL2089291)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485620BDBM50485620(CHEMBL2089293)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21447BDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485621BDBM50485621(CHEMBL2089281)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer/Induced myeloid leukemia cell differentiation protein Mcl-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485615BDBM50485615(CHEMBL2089282)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485616BDBM50485616(CHEMBL2089286)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485617BDBM50485617(CHEMBL2089289)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485618BDBM50485618(CHEMBL2089290)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mcl1-BAK interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50107130BDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataKd:  8.40E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50107130BDBM50107130((Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazo...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50330250BDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 1.22E+5nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50591667BDBM50591667(CHEMBL5170330)
Affinity DataKi:  2.61E+5nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed