Compile Data Set for Download or QSAR
Report error Found 16440 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1'
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM14320(CHEMBL62083 | 1-amino-isoquinoline | fragment 1 (J...)
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM14322(CHEMBL61236 | 2-aminoquinoline | fragment 2 (J. me...)
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM15788(4-[(4-fluorophenyl)methyl]piperidine | CHEMBL12043...)
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1 [1-453](Human)
Novartis

LigandPNGBDBM29751(macrocyclic peptidomimetic, 3e)
Affinity DatapH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50240572(CHEMBL4078781)
Affinity DataEC50:  184nMAssay Description:Inhibition of BACE1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50240554(CHEMBL4081377)
Affinity DataEC50:  3.5nMAssay Description:Inhibition of BACE1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50240557(CHEMBL4065655)
Affinity DataEC50:  19nMAssay Description:Inhibition of BACE1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50240569(CHEMBL4067893)
Affinity DataEC50:  80nMAssay Description:Inhibition of BACE1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2019
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259797(CHEMBL4074001)
Affinity DataEC50:  410nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259798(CHEMBL4095483)
Affinity DataEC50:  670nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259799(CHEMBL4078427)
Affinity DataEC50:  290nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259806(CHEMBL4100768)
Affinity DataEC50:  810nMAssay Description:Inhibition of BACE1 in human H4 cells expressing human APP K595N/M596L double mutant assessed as decrease in amyloid beta 42 and amyloid beta 40 leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259802(CHEMBL4071284)
Affinity DataEC50:  590nMAssay Description:Inhibition of BACE1 in human H4 cells expressing human APP K595N/M596L double mutant assessed as decrease in amyloid beta 42 and amyloid beta 40 leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259801(CHEMBL4092083)
Affinity DataEC50:  1.33E+3nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259805(CHEMBL4065393)
Affinity DataEC50:  880nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259804(CHEMBL4075051)
Affinity DataEC50:  350nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259800(CHEMBL4062635)
Affinity DataEC50:  1.21E+3nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50259803(CHEMBL4093064)
Affinity DataEC50:  480nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270762(CHEMBL4128727)
Affinity DataKd:  1.23E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270763(CHEMBL4128586)
Affinity DataKd:  861nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270756(CHEMBL4128807)
Affinity DataKd:  1.03E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270769(CHEMBL4128947)
Affinity DataKd:  2.14E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270759(CHEMBL4127412)
Affinity DataKd:  1.33E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270760(CHEMBL4127550)
Affinity DataKd:  1.88E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270757(CHEMBL4126598)
Affinity DataKd:  1.74E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270766(CHEMBL4127672)
Affinity DataKd:  554nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270767(CHEMBL4127062)
Affinity DataKd:  213nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270768(CHEMBL4128447)
Affinity DataKd:  169nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270764(CHEMBL4127986)
Affinity DataKd:  1.43E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270770(CHEMBL4126751)
Affinity DataKd:  1.84E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270765(CHEMBL4127289)
Affinity DataKd:  1.75E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50270761(CHEMBL4129873)
Affinity DataKd:  1.44E+3nMAssay Description:Binding affinity to BACE1 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50462838(CHEMBL4239092)
Affinity DataEC50:  343nMAssay Description:Inhibition of BACE1 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50493641(CHEMBL2437454)
Affinity DataKd:  2.68E+4nMAssay Description:Binding affinity to human recombinant BACE1 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50493642(CHEMBL2437452)
Affinity DataKd:  3.66E+4nMAssay Description:Binding affinity to human recombinant BACE1 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50134706(5-{2-[4-(2-Biphenyl-2-yl-2-hydroxy-acetylamino)-5-...)
Affinity DataEC50:  1.00E+4nMAssay Description:Compound was tested for its effective concentration against human beta-Secretase (BACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50134705(5-{2-[4-(2-Biphenyl-2-yl-2-hydroxy-acetylamino)-5-...)
Affinity DataEC50:  4.00E+3nMAssay Description:Compound was tested for its effective concentration against human beta-Secretase (BACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171338(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataEC50:  2.70E+4nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171337(5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...)
Affinity DataEC50:  23nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171339(CHEMBL190346 | cid_11198061 | 1-(3-Acetyl-phenyl)-...)
Affinity DataEC50:  11nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1/2(Human)
University of ZüRich

Curated by ChEMBL
LigandPNGBDBM50171340(5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...)
Affinity DataEC50:  3.5nMAssay Description:Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50196751(N-((S)-1-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-di...)
Affinity DataEC50:  1nMAssay Description:Inhibition of BACE expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50196747(N-((S)-1-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-di...)
Affinity DataEC50:  9nMAssay Description:Inhibition of BACE expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50196753(N-((S)-1-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-di...)
Affinity DataEC50:  48nMAssay Description:Inhibition of BACE expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50196735(N-((S)-1-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-di...)
Affinity DataEC50:  76nMAssay Description:Inhibition of BACE expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50196742(N-((S)-1-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-di...)
Affinity DataEC50:  59nMAssay Description:Inhibition of BACE expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50196749(pyridin-4-ylmethyl (S)-1-((2S,3R)-4-(3-ethylbenzyl...)
Affinity DataEC50:  5nMAssay Description:Inhibition of BACE expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50196733(pyridin-3-ylmethyl (S)-1-((2S,3R)-4-(3-ethylbenzyl...)
Affinity DataEC50:  5nMAssay Description:Inhibition of BACE expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50196743(pyridin-4-ylmethyl (S)-1-((2S,3R)-4-(3-ethylbenzyl...)
Affinity DataEC50:  2nMAssay Description:Inhibition of BACE expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astex

LigandPNGBDBM50196756(pyridin-3-ylmethyl (S)-1-((2S,3R)-4-(3-ethylbenzyl...)
Affinity DataEC50:  0.600nMAssay Description:Inhibition of BACE expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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