Report error Found 171 Enz. Inhib. hit(s) with Target = 'CREB-binding protein/Histone acetyltransferase p300'
Affinity DataEC50: 3.20nMAssay Description:Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6.30nMAssay Description:Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6.60nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
Affinity DataEC50: 7.90nMAssay Description:Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKd: 18nMAssay Description:Binding affinity to His-tagged human CH1 domain of p300 (323 to 423 residues)expressed in Escherichia coli Rosetta (DE3)/CBP (unknown origin) by fluo...More data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding affinity to His-tagged human CH1 domain of p300 (323 to 423 residues)expressed in Escherichia coli Rosetta (DE3)/CBP (unknown origin) by fluo...More data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding affinity to human N-terminal His10-tagged/C-terminal Biotin-tagged CBP (R1081 to G1198 residues)/P300 expressed in Escherichia coli BL21(DE3)...More data for this Ligand-Target Pair
Affinity DataKd: 22nMAssay Description:Binding affinity to His-tagged human CH1 domain of p300 (323 to 423 residues)expressed in Escherichia coli Rosetta (DE3)/CBP (unknown origin) by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 30nMAssay Description:Binding affinity to His-tagged human CH1 domain of p300 (323 to 423 residues)expressed in Escherichia coli Rosetta (DE3)/CBP (unknown origin) by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
Affinity DataKd: 32nMAssay Description:Binding affinity to His-tagged human CH1 domain of p300 (323 to 423 residues)expressed in Escherichia coli Rosetta (DE3)/CBP (unknown origin) by fluo...More data for this Ligand-Target Pair
Affinity DataKd: 34nMAssay Description:Binding affinity to His-tagged human CH1 domain of p300 (323 to 423 residues)expressed in Escherichia coli Rosetta (DE3)/CBP (unknown origin) by fluo...More data for this Ligand-Target Pair
Affinity DataKd: 36nMAssay Description:Binding affinity to His-tagged human CH1 domain of p300 (323 to 423 residues)expressed in Escherichia coli Rosetta (DE3)/CBP (unknown origin) by fluo...More data for this Ligand-Target Pair
Affinity DataKd: 37nMAssay Description:Binding affinity to His-tagged human CH1 domain of p300 (323 to 423 residues)expressed in Escherichia coli Rosetta (DE3)/CBP (unknown origin) by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of p300/CBP in human PC3 cells assessed as reduction in acetylated H3K27 levels after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of p300/CBP in human PC3 cells assessed as reduction in acetylated H3K27 levels after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 53nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 69nMAssay Description:Inhibition of CBP/EP300 in human MOLM16 cells assessed as decrease in MYC expression measured after 4 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 76nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assayMore data for this Ligand-Target Pair
























3D Structure (crystal)






















