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Report error Found 5347 Enz. Inhib. hit(s) with Target = 'Cathepsin D'
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50030745(CHEMBL3342185 | acs.jmedchem.1c00409_ST.412)
Affinity DataKi:  0.00143nMAssay Description:Inhibition of human cathepsin K using Z-Leu-Arg-AMC fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataKd:  0.00371nMAssay Description:Binding affinity against Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50030746(CHEMBL3342184 | acs.jmedchem.1c00409_ST.413)
Affinity DataKi:  0.00420nMAssay Description:Inhibition of human cathepsin K using Z-Leu-Arg-AMC fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50030747(CHEMBL3342183)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of human cathepsin K using Z-Leu-Arg-AMC fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human cathepsin D using GKPILFFRLK(DNP)-D-RNH2) labeled MCA as substrate preincubated for 10 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50400214(CHEMBL2181022)
Affinity DataIC50: 0.0783nMAssay Description:Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50400214(CHEMBL2181022)
Affinity DataIC50: 0.0783nMAssay Description:Inhibition of cathepsin D by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of secreted cathepsin D in human MDA-MB-231 cells using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2020
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045281(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50400213(CHEMBL2181024)
Affinity DataIC50: 0.126nMAssay Description:Inhibition of cathepsin D by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 0.173nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50603524(CHEMBL5192597)
Affinity DataIC50: 0.178nMAssay Description:Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 15 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2020
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045290(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50643516(CHEMBL5569371)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Cathepsin D using MCA labeled GKPILFFRLK(DNP)-D-R-NH2 as substrate preincubated for 10 mins followed by substrate addition by FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50377588(CHEMBL257594)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCathepsin D(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of cathepsin D.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of human cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045285(2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propion...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50506541(CHEMBL4576166)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50312541(((S)-1-[(S)-1-[(1S,2S,4R)-4-((S)-1-Benzylcarbamoyl...)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human liver cathepsin D after 20 mins by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 0.693nMAssay Description:Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 0.693nMAssay Description:Inhibition of cathepsin D by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50084670(N-[3-[2-(2-Bromo-4,5-dimethoxy-phenoxy)-acetylamin...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against aspartic proteasesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50169103(Pyridine-2-carboxylic acid {(S)-1-[(1S,2S)-3-[(S)-...)
Affinity DataKi:  0.700nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50080960(2-Bromo-N-[(1S,2S)-3-{[2-(2,4-dichloro-phenyl)-eth...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human liver Cathepsin D using (Ac-Glu-Glu(Edans)-Lys-Pro-Ile-Cys-Phe-PheArg-Leu-Gly-Lys(Dabcyl)-Glu-NH2) peptide as substrate by fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50080960(2-Bromo-N-[(1S,2S)-3-{[2-(2,4-dichloro-phenyl)-eth...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50080960(2-Bromo-N-[(1S,2S)-3-{[2-(2,4-dichloro-phenyl)-eth...)
Affinity DataIC50: 0.700nMAssay Description:Inhibitory activity against human liver Cathepsin D using Cathepsin D assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50333945((S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methy...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045291(i2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propio...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50437552(CHEMBL2407339)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of Cathepsin D (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCathepsin D(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50025542(3-Hydroxy-4-{3-methyl-2-[3-methyl-2-(3-methyl-buty...)
Affinity DataKi:  1nMAssay Description:Inhibition of cathepsin D.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50305527((4S)-4-[(1R)-1-hydroxy-2-({1-[3-(1-methylethyl)phe...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50294218((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCathepsin D(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50022521(Boc-Phe-His-Cha-CH2-S-Leu-NHCO(CH2)2C6H5 | CHEMBL3...)
Affinity DataIC50: 1nMpH: 3.2Assay Description:Inhibition of bovine cathepsin D at pH 3.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50438363(CHEMBL2408751)
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin-D (unknown origin) using C-terminal biotinylated peptide substrate treated 30 mins before addition of peptide substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM912(PEPSTATIN | Pepstatine | N-[(3-Methyl-1-oxobutyl)-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM232262(US9345742, 20)
Affinity DataIC50: 1nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details
US Patent

TargetCathepsin D(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50022518(Pro-His-Pro-Phe-His-Leu-CH2NH-Val-Ile-His-Lys-OH |...)
Affinity DataIC50: 1nMpH: 3.3Assay Description:Inhibition of bovine cathepsin D at pH 3.3(no inhibition)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50506521(CHEMBL4558691)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human placenta CatD using Abz-Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu as substrate preincubated for 10 mins followed by substrate addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCathepsin D(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50025528(2-[2-(4-{2-[2-(2-tert-Butoxycarbonylamino-3-phenyl...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of cathepsin D.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetCathepsin D(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50025511({1-[1-(1-{1-Hydroxy-2-[1-(3-methyl-butylcarbamoyl)...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of cathepsin D.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50076285(1-Acetyl-piperidine-4-carboxylic acid (2-benzo[1,3...)
Affinity DataKi:  1.30nMAssay Description:Compound was tested for the inhibitory activity against human liver cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50042296(CHEMBL3352906)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human cathepsin K using Z-Leu-Arg-AMC fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50169104(Pyridine-2-carboxylic acid {(S)-1-[(1S,2S)-3-[(S)-...)
Affinity DataKi:  1.60nMAssay Description:Inhibitory concentration against the human Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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