Compile Data Set for Download or QSAR
Report error Found 217 Enz. Inhib. hit(s) with Target = 'Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A'
LigandPNGBDBM27427(8-methyl-11-thia-9,14,16-triazatetracyclo[8.7.0.0^...)
Affinity DataKi:  0.5nM ΔG°:  -55.2kJ/mole IC50: 5nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27428(12-ethyl-11,13-dimethyl-8-thia-3,5,10-triazatricyc...)
Affinity DataKi:  1nM ΔG°:  -53.4kJ/mole IC50: 10nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27371(2-(2-aminopyrimidin-4-yl)-7,7-dimethyl-1H,4H,5H,6H...)
Affinity DataIC50: 2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27359(7-ethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)
Affinity DataIC50: 2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27362(7-(2-fluoroethyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-...)
Affinity DataIC50: 2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27391(5,13,17-triazatetracyclo[8.7.0.0^{2,7}.0^{11,16}]h...)
Affinity DataIC50: 2nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27380((7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)
Affinity DataIC50: 2nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27429(9-methyl-17-thia-2,12,14-triazatetracyclo[8.7.0.0^...)
Affinity DataKi:  2nM ΔG°:  -51.6kJ/mole IC50: 20nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27430(11,13-dimethyl-12-(prop-2-en-1-yl)-8-thia-3,5,10-t...)
Affinity DataKi:  2nM ΔG°:  -51.6kJ/mole IC50: 20nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27431(7-methyl-10-thia-8,13,15-triazatetracyclo[7.7.0.0^...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/mole IC50: 30nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27361(7-cyclobutyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)
Affinity DataIC50: 3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27363(7,7-dimethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrro...)
Affinity DataIC50: 3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27348(6-(2-methylpropyl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H...)
Affinity DataIC50: 3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27413(2-(2-aminopyrimidin-4-yl)-1-(2-fluoroethyl)-1H,4H,...)
Affinity DataIC50: 3nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27370(2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1H,4H,...)
Affinity DataIC50: 3nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27432(11,12,13-trimethyl-8-thia-3,5,10-triazatricyclo[7....)
Affinity DataKi:  4nM ΔG°:  -49.9kJ/mole IC50: 40nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27377(2-(2-aminopyrimidin-4-yl)-7-(2-hydroxyethyl)-1H,4H...)
Affinity DataIC50: 4nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27390(2-(2-amino-5-bromopyrimidin-4-yl)-1H,4H,5H,6H,7H-p...)
Affinity DataIC50: 4nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27412(2-(2-aminopyrimidin-4-yl)-1-(cyclopropylmethyl)-1H...)
Affinity DataIC50: 4nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27368(2-(2-aminopyrimidin-4-yl)-7-(propan-2-yl)-1H,4H,5H...)
Affinity DataIC50: 4nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27372(2-(2-aminopyrimidin-4-yl)-7,7-diethyl-1H,4H,5H,6H,...)
Affinity DataIC50: 5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27433(16-methyl-8-thia-3,5,10-triazatetracyclo[7.7.0.0^{...)
Affinity DataKi:  5nM ΔG°:  -49.3kJ/mole IC50: 50nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
LigandPNGBDBM27406(2-(2-aminopyrimidin-4-yl)-1-(2,2,2-trifluoroethyl)...)
Affinity DataIC50: 5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27347(6-cyclopropyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrr...)
Affinity DataIC50: 5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27379((7R)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1...)
Affinity DataIC50: 5nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27367(2-(2-aminopyrimidin-4-yl)-7-ethyl-1H,4H,5H,6H,7H-p...)
Affinity DataIC50: 5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27369(2-(2-aminopyrimidin-4-yl)-7-cyclobutyl-1H,4H,5H,6H...)
Affinity DataIC50: 5nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27346(6-(propan-2-yl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-py...)
Affinity DataIC50: 6nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27364(7,7-diethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrol...)
Affinity DataIC50: 6nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27366(2-(2-aminopyrimidin-4-yl)-7-methyl-1H,4H,5H,6H,7H-...)
Affinity DataIC50: 6nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27351(2-(2-aminopyrimidin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50: 7nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27375(2-(2-aminopyrimidin-4-yl)-7-[2-(benzyloxy)ethyl]-1...)
Affinity DataIC50: 7nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27421(2-[2-(phenylamino)pyrimidin-4-yl]-1H,4H,5H,6H,7H-p...)
Affinity DataIC50: 7nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27351(2-(2-aminopyrimidin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50: 7nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27355(2-(2-aminopyrimidin-4-yl)-6-(2-methylpropyl)-1H,4H...)
Affinity DataIC50: 8nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27404(2-(2-aminopyrimidin-4-yl)-1-ethyl-1H,4H,5H,6H,7H-p...)
Affinity DataIC50: 8nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27382(2-(3-fluoropyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)
Affinity DataIC50: 9nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27358(7-methyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50: 10nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27374(2-(2-aminopyrimidin-4-yl)-7-(3,3,3-trifluoropropyl...)
Affinity DataIC50: 10nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27344(JMC502647 Compound 8 | 2-(pyridin-4-yl)-1H,4H,5H,6...)
Affinity DataIC50: 10nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27360(7-(propan-2-yl)-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-py...)
Affinity DataIC50: 10nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27344(JMC502647 Compound 8 | 2-(pyridin-4-yl)-1H,4H,5H,6...)
Affinity DataIC50: 10nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27354(2-(2-aminopyrimidin-4-yl)-6-cyclopropyl-1H,4H,5H,6...)
Affinity DataIC50: 11nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27378(2-(2-aminopyrimidin-4-yl)-7-(3-hydroxypropyl)-1H,4...)
Affinity DataIC50: 12nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27407(2-(2-aminopyrimidin-4-yl)-1-propyl-1H,4H,5H,6H,7H-...)
Affinity DataIC50: 12nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27353(2-(2-aminopyrimidin-4-yl)-6-(propan-2-yl)-1H,4H,5H...)
Affinity DataIC50: 12nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27345(6-methyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3...)
Affinity DataIC50: 13nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2009
Entry Details Article
PubMed
LigandPNGBDBM27411(2-(2-aminopyrimidin-4-yl)-1-(2-methylpropyl)-1H,4H...)
Affinity DataIC50: 13nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27384(2-{1H-pyrrolo[2,3-b]pyridin-4-yl}-1H,4H,5H,6H,7H-p...)
Affinity DataIC50: 14nMpH: 7.9 T: 2°CAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
LigandPNGBDBM27409(2-(2-aminopyrimidin-4-yl)-1-cyclobutyl-1H,4H,5H,6H...)
Affinity DataIC50: 14nMAssay Description:The potency of the compound toward kinase activity was determined using a Dowex resin-based assay. The substrate was phosphorylated by kinase in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2009
Entry Details Article
PubMed
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