Compile Data Set for Download or QSAR
Report error Found 869 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B'
LigandPNGBDBM50191929(2-(4-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50191913(N-(2-methyl-4-(2-(pyrrolidin-1-yl)ethyl)phenyl)-4-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50191918(N-(2-methyl-4-(2-(piperidin-1-yl)ethyl)phenyl)-4-(...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50191924(N-(2-methyl-4-(2-morpholinoethyl)phenyl)-4-(1H-pyr...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50191922(trans-N1-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimid...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 2.63nMAssay Description:Compounds of the present disclosure were tested in a 10-dose IC50 mode with a 3-fold serial dilution starting from 0.5 μM, and the control compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

LigandPNGBDBM50191925(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-o-tolylpyrimid...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50338873(N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Cyclin B-cyclin-dependent kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM5595(4-{[4-amino-6-(cyclohexylmethoxy)-5-nitrosopyrimid...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM7478(CHEMBL23254 | 2-chloro-4-[(2-{[(2R)-1-hydroxy-3-me...)
Affinity DataIC50: 6nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-33P] ATP. 33...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2006
Entry Details Article
PubMed
LigandPNGBDBM7478(CHEMBL23254 | 2-chloro-4-[(2-{[(2R)-1-hydroxy-3-me...)
Affinity DataIC50: 6nMAssay Description:Inhibition of cyclin dependent kinase 1-cyclinBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
LigandPNGBDBM50191914(N-(2-chlorophenyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-y...)
Affinity DataIC50: 9nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM5545(4-{[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino}-N-m...)
Affinity DataIC50: 9nMAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM7501(CHEMBL48362 | 4-{[(2Z)-4,6-dihydroxy-7-(1-methylpi...)
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence ATP/ [gamma-32P] ATP. 32P incorpo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM5544(4-{[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino}benz...)
Affinity DataIC50: 9.5nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM5544(4-{[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino}benz...)
Affinity DataIC50: 9.5nMAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2005
Entry Details Article
PubMed
LigandPNGBDBM50395892(CHEMBL2163772)
Affinity DataKi:  10nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM10642(CHEMBL83320 | 2-[({2-[(1-hydroxy-3-methylbutan-2-y...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2006
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Cyclin B-cyclin-dependent kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50191919(N-(2-bromophenyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50191912(N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyri...)
Affinity DataIC50: 14nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM684220(US20240218021, Example 206)
Affinity DataIC50: 20nMAssay Description:FP binding assays were performed in 25 mM HEPES pH 7.5, 100 mM NaCl, 1 mM DTT, 0.01% NP-40 and 1 mg/mL BSA for all 3 protein complexes in black 96-we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM683991(US20240218021, Example 438)
Affinity DataIC50: 20nMAssay Description:FP binding assays were performed in 25 mM HEPES pH 7.5, 100 mM NaCl, 1 mM DTT, 0.01% NP-40 and 1 mg/mL BSA for all 3 protein complexes in black 96-we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM684472(US20240218021, Example 333)
Affinity DataIC50: 20nMAssay Description:FP binding assays were performed in 25 mM HEPES pH 7.5, 100 mM NaCl, 1 mM DTT, 0.01% NP-40 and 1 mg/mL BSA for all 3 protein complexes in black 96-we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM683811(US20240218021, Example 348)
Affinity DataIC50: 20nMAssay Description:FP binding assays were performed in 25 mM HEPES pH 7.5, 100 mM NaCl, 1 mM DTT, 0.01% NP-40 and 1 mg/mL BSA for all 3 protein complexes in black 96-we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM684383(US20240218021, Example 288)
Affinity DataIC50: 20nMAssay Description:FP binding assays were performed in 25 mM HEPES pH 7.5, 100 mM NaCl, 1 mM DTT, 0.01% NP-40 and 1 mg/mL BSA for all 3 protein complexes in black 96-we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2024
Entry Details
US Patent

LigandPNGBDBM50366800(OLOMOUCINE II)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM684468(US20240218021, Example 331)
Affinity DataIC50: 20nMAssay Description:FP binding assays were performed in 25 mM HEPES pH 7.5, 100 mM NaCl, 1 mM DTT, 0.01% NP-40 and 1 mg/mL BSA for all 3 protein complexes in black 96-we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2024
Entry Details
US Patent

LigandPNGBDBM50169892(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM7491(4-[2-Amino-5-oxo-1,5-dihydro-imidazol-(4Z)-ylidene...)
Affinity DataIC50: 22nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2006
Entry Details Article
PubMed
LigandPNGBDBM7491(4-[2-Amino-5-oxo-1,5-dihydro-imidazol-(4Z)-ylidene...)
Affinity DataIC50: 22nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
LigandPNGBDBM7238(cid_5289419 | 3-(3H-Imidazol-4-ylmethylene)-5-meth...)
Affinity DataIC50: 22nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
LigandPNGBDBM7263(CHEMBL299756 | 9-oxo-8,18-diazatetracyclo[9.7.0.0^...)
Affinity DataIC50: 24nMAssay Description:Inhibition of CDK1/cyclin B expressed in M phase starfish oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM7263(CHEMBL299756 | 9-oxo-8,18-diazatetracyclo[9.7.0.0^...)
Affinity DataIC50: 24nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM7264(NSC 709125 | 4,5-dimethoxy-14-nitro-8,18-diazatetr...)
Affinity DataIC50: 24nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM7492(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Affinity DataIC50: 25nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2006
Entry Details Article
PubMed
LigandPNGBDBM50191928(1-(3-(2-(cyclohexylamino)pyrimidin-4-yl)-1H-pyrrol...)
Affinity DataIC50: 31nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM750529(US20250195475, Example 181)
Affinity DataIC50: 34.4nMAssay Description:Compound Preparation. Dissslove the compounds into DMSO solution to make 10 mM DMSO stock. Serially dilute the stock solution from highest concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

LigandPNGBDBM7262(NSC 705701 | BDBM84528 | alsterpaullone | 9-Nitrop...)
Affinity DataIC50: 35nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
LigandPNGBDBM7262(NSC 705701 | BDBM84528 | alsterpaullone | 9-Nitrop...)
Affinity DataIC50: 35nMAssay Description:Inhibition of CDK1/cyclin B expressed in M phase starfish oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM7262(NSC 705701 | BDBM84528 | alsterpaullone | 9-Nitrop...)
Affinity DataIC50: 35nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2006
Entry Details Article
PubMed
LigandPNGBDBM50191916(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-p-tolylpyrimid...)
Affinity DataIC50: 40nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50191923(N-(2-methoxyphenyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Shengke Pharmaceuticals (Jiangsu)

US Patent
LigandPNGBDBM7265(NSC 708244 | 4,5-dimethoxy-9-oxo-8,18-diazatetracy...)
Affinity DataIC50: 44nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2006
Entry Details Article
PubMed
LigandPNGBDBM7265(NSC 708244 | 4,5-dimethoxy-9-oxo-8,18-diazatetracy...)
Affinity DataIC50: 44nMAssay Description:Inhibition of CDK1/cyclin B expressed in M phase starfish oocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
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