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Report error Found 53 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 8/19'
TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585705(CHEMBL4856755 | US12281080, SCCP 6219)
Affinity DataIC50: 3.70nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataIC50: 3.80nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM731283(US12281080, SCCP 6216)
Affinity DataIC50: 4.10nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585701(CHEMBL5080406 | US12281080, SCCP 6299)
Affinity DataIC50: 4.60nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM731287(US12281080, SCCP 6295)
Affinity DataIC50: 5.80nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585696(CHEMBL4851694 | US12281080, SCCP 6283)
Affinity DataIC50: 5.80nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585703(CHEMBL5094174 | US12281080, SCCP 6346)
Affinity DataIC50: 6.5nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585704(CHEMBL5077066 | US12281080, SCCP 6345)
Affinity DataIC50: 8.10nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585706(CHEMBL5087807 | US12281080, SCCP 6337)
Affinity DataIC50: 9.20nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585707(CHEMBL5091221 | US12281080, SCCP 6336)
Affinity DataIC50: 9.30nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585699(CHEMBL5094334 | US12281080, SCCP 6294)
Affinity DataIC50: 9.70nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585697(CHEMBL5086592 | US12281080, SCCP 6326)
Affinity DataIC50: 11.7nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585698(CHEMBL5083266 | US12281080, SCCP 6440)
Affinity DataIC50: 18.9nMAssay Description:In vitro binding of the compounds to the ATP pocket of CDK8 in complex with Cyclin C was carried out by LanthaScreen® Eu Kinase Binding Assay based o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)
Affinity DataEC50:  20nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataEC50:  20nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM576466(US11471446, Compound DBA-7)
Affinity DataEC50:  25nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataEC50:  50nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50353900(CHEMBL4174408 | US12325725, Compound 39)
Affinity DataIC50: 100nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50353060(CHEMBL4167193 | US12325725, Compound 33)
Affinity DataIC50: 100nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50355502(CHEMBL4159279 | US12325725, Compound 25)
Affinity DataIC50: 100nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50361153(CHEMBL4162650 | US12325725, Compound 23)
Affinity DataIC50: 100nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50361159(CHEMBL4170978 | US12325725, Compound 47)
Affinity DataIC50: 100nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50361154(CHEMBL4173827 | US12325725, Compound 8a)
Affinity DataIC50: 100nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50361156(CHEMBL4160370 | US12325725, Compound 34)
Affinity DataIC50: 150nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM747901(US12325725, Compound 32)
Affinity DataIC50: 150nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50361162(CHEMBL4164953 | US12325725, Compound 1)
Affinity DataIC50: 150nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM747882(US12325725, Compound 22r)
Affinity DataIC50: 150nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM747967(US12325725, Compound I-2)
Affinity DataIC50: 150nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50358018(CHEMBL4172737 | US12325725, Compound 10)
Affinity DataIC50: 150nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM747966(US12325725, Compound I-1)
Affinity DataIC50: 150nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM576465(US11471446, Compound DBA-6)
Affinity DataEC50:  180nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50542373(CHEMBL4637411 | US12325725, Compound 24)
Affinity DataIC50: 250nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM747968(US12325725, Compound I-3)
Affinity DataIC50: 250nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50353059(CHEMBL4169344 | US12325725, Compound 8b)
Affinity DataIC50: 250nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM747969(US12325725, Compound I-5)
Affinity DataIC50: 500nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50353038(CHEMBL4175290 | US12325725, Compound 11)
Affinity DataIC50: 500nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50459994(CHEMBL4226806 | US11471446, Compound DBA-8)
Affinity DataEC50:  500nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM576460(US11471446, Compound DBA-1)
Affinity DataEC50:  1.20E+3nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50361161(CHEMBL4170388 | US12325725, Compound 5)
Affinity DataIC50: 1.35E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50361155(CHEMBL4176230 | US12325725, Compound 2)
Affinity DataIC50: 1.35E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50354985(CHEMBL4163735 | US12325725, Compound 46)
Affinity DataIC50: 1.35E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM576464(US11471446, Compound DBA-5)
Affinity DataEC50:  1.70E+3nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM576463(US11471446, Compound DBA-4)
Affinity DataEC50:  2.80E+3nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50360454(CHEMBL4166041 | US12325725, Compound 4)
Affinity DataIC50: 4.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50355811(CHEMBL4170582 | US12325725, Compound 14)
Affinity DataIC50: 4.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50359794(CHEMBL4162472 | US12325725, Compound 7)
Affinity DataIC50: 6.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50353057(CHEMBL4176653 | US12325725, Compound 6)
Affinity DataIC50: 6.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50360468(CHEMBL4168375 | US12325725, Compound 3)
Affinity DataIC50: 6.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50356108(CHEMBL4167414 | US12325725, Compound 13)
Affinity DataIC50: 6.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50361160(CHEMBL4162058 | US12325725, Compound 12)
Affinity DataIC50: 6.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

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