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Report error Found 94 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-beta'
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286494(5-Cyclopropyl-2-(4-dimethylamino-cyclohexyl)-7-(2,...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286490(5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50:  2.70E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM87351(m-AMSA | N-[4-(acridin-9-ylamino)-3-methoxyphenyl]...)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286489(5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286492(2-(4-Amino-cyclohexyl)-5-cyclopropyl-7-(2,6-dimeth...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataEC50: >7.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286486(5-Cyclopropyl-2-(2-dimethylamino-ethyl)-7-(2,6-dim...)
Affinity DataEC50:  930nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286491(5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286496(2-(4-Amino-cyclohexyl)-5-cyclopropyl-7-(2,6-dimeth...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286488(5-Cyclopropyl-2-(4-dimethylamino-cyclohexyl)-7-(2,...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286497(N-{4-[5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-...)
Affinity DataEC50: >5.10E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50045698(WIN-57294 | 1-Cyclopropyl-7-(2,6-dimethyl-pyridin-...)
Affinity DataEC50: >5.40E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286495(5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286493([5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-d...)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286499(5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286498(N-{4-[5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-...)
Affinity DataEC50: >5.20E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286501(5-Cyclopropyl-2-(3-dimethylamino-propyl)-7-(2,6-di...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286500(5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286485(5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286487([5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-d...)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50045706(1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50: >5.50E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286474(5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50286484(2-Cyclohexyl-5-cyclopropyl-7-(2,6-dimethyl-pyridin...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.18E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  7.32E+5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50449890(CHEMBL4161876)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50449891(CHEMBL4174756)
Affinity DataIC50: 13nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50410828(CHEMBL5266387)
Affinity DataIC50: 26nMAssay Description:Inhibition of human DNA topoisomerase 2-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520631(Ametantrone)
Affinity DataIC50: 30nMAssay Description:Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50449889(CHEMBL4160802)
Affinity DataIC50: 32nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50449888(CHEMBL4172196)
Affinity DataIC50: 81nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50449887(CHEMBL4169404)
Affinity DataIC50: 110nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50547613(CHEMBL4751362)
Affinity DataIC50: 130nMAssay Description:Inhibition of Topoisomerase II beta (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50473498(Ro-616653 | CHEMBL157831)
Affinity DataIC50: 157nMAssay Description:Antibacterial activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50473498(Ro-616653 | CHEMBL157831)
Affinity DataIC50: 157nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50473499(BAY-507950 | CHEMBL156813)
Affinity DataIC50: 326nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229974(CHEMBL178077)
Affinity DataIC50: 452nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50473499(BAY-507950 | CHEMBL156813)
Affinity DataIC50: 489nMAssay Description:Antibacterial activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50623278(CHEMBL5408150)
Affinity DataIC50: 550nMAssay Description:Inhibition of human DNA topoisomerase 2 beta assessed as relaxation of supercoiled plasmid pBR322 DNA incubated for 30 mins by ethidium bromide stain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50458474(CHEMBL4213218)
Affinity DataIC50: 580nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 603nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50473497(BAY-507952 | CHEMBL157769)
Affinity DataIC50: 625nMAssay Description:Antibacterial activity against Micrococcus luteus DNA gyrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229967(CHEMBL263944)
Affinity DataIC50: 666nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229969(CHEMBL554645)
Affinity DataIC50: 727nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 727nMAssay Description:Inhibition of Topoisomerase II beta (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50473497(BAY-507952 | CHEMBL157769)
Affinity DataIC50: 781nMAssay Description:Antibacterial activity against Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 790nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50229970(CHEMBL367876)
Affinity DataIC50: 796nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2019
Entry Details Article
PubMed
TargetDNA topoisomerase 2-beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50458475(CHEMBL4205327)
Affinity DataIC50: 860nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
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