Compile Data Set for Download or QSAR
Report error Found 3831 Enz. Inhib. hit(s) with Target = 'Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B'
LigandPNGBDBM168127(US9073936, 2 | US9598426, 2)
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM50277665(4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl...)
Affinity DataIC50: 1.79E+7nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM50229879(CHEMBL430685)
Affinity DataIC50: 3.37E+5nMAssay Description:Inhibition of bovine heart phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2019
Entry Details Article
PubMed
LigandPNGBDBM50229882(CHEMBL111902)
Affinity DataIC50: 2.67E+5nMAssay Description:Inhibition of bovine heart phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2019
Entry Details Article
PubMed
LigandPNGBDBM14769(6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14772(5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazoli...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 2.00E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50: 1.90E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM86642(BC11-38 | US9173884, BC11-38)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
US Patent

LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
US Patent

LigandPNGBDBM86639(BC11-15 | US9173884, BC11-15)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
US Patent

LigandPNGBDBM86644(BC11-38-2 | US9173884, BC11-38-2)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
US Patent

LigandPNGBDBM86645(BC11-38-3 | US9173884, BC11-38-3)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
US Patent

LigandPNGBDBM86646(BC11-38-4 | US9173884, BC11-38-4)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
US Patent

LigandPNGBDBM15296(Milrinone | CHEMBL189 | 6-methyl-2-oxo-5-pyridin-4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of phosphodiesterase 1 (PDE I)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

LigandPNGBDBM50015754(CHEMBL308834 | (8-Fluoro-[1,2,4]triazolo[4,3-a]qui...)
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluated for Ca++ dependent phosphodiesterase activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50015782(CHEMBL72398 | (7-Fluoro-[1,2,4]triazolo[4,3-a]quin...)
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluated for Ca++ dependent phosphodiesterase activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluated for Ca++ dependent phosphodiesterase activity. More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataIC50: 9.20E+4nMAssay Description:Inhibition of bovine heart phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2019
Entry Details Article
PubMed
LigandPNGBDBM86643(BC11-38-1 | US9173884, BC11-38-1)
Affinity DataIC50: 9.00E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
US Patent

LigandPNGBDBM14773(Ariflo | 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyph...)
Affinity DataIC50: 8.70E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM50229880(CHEMBL116115)
Affinity DataIC50: 8.10E+4nMAssay Description:Inhibition of bovine heart phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2019
Entry Details Article
PubMed
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataIC50: 7.00E+4nMAssay Description:Evaluated for Ca++ dependent phosphodiesterase activity. More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50229878(CHEMBL112904)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of bovine heart phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2019
Entry Details Article
PubMed
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 6.80E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM50277784(N,N,2-trimethyl-5-nitrobenzenesulfonamide | CHEMBL...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of human PDE1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50568657(CHEMBL4872870)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
LigandPNGBDBM50560855(CHEMBL4745832)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE1B (10-487 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE1B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM426311(US10513524, Compound (P1))
Affinity DataIC50: 4.51E+4nMAssay Description:PDE1 assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 (sufficient to con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
US Patent

LigandPNGBDBM50459162(CHEMBL4218772)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM98933(US8497265, 345)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2016
Entry Details Article
PubMed
LigandPNGBDBM99145(US8497265, 894)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human PDE1B using FAM-cAMP substrate by TR-FRET progressive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2016
Entry Details Article
PubMed
LigandPNGBDBM433321(US10561656, Example 3-A | (6aR,9aS)-5,6a,7,8,9,9a-...)
Affinity DataIC50: 2.70E+4nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

LigandPNGBDBM50229881(CHEMBL114797)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of bovine heart phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2019
Entry Details Article
PubMed
LigandPNGBDBM50015817(CHEMBL442176 | (8-Fluoro-1-trifluoromethyl-[1,2,4]...)
Affinity DataIC50: 2.40E+4nMAssay Description:Evaluated for Ca++ dependent phosphodiesterase activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50513788(CHEMBL4558162)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PDE1B catalytic domain (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50560857(CHEMBL4794748)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human PDE1B (10-487 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50015778(CHEMBL73210 | Ethyl-(1-ethyl-[1,2,4]triazolo[4,3-a...)
Affinity DataIC50: 2.00E+4nMAssay Description:Evaluated for Ca++ dependent phosphodiesterase activity.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50398649(CHEMBL2178115 | US9617269, Compound WYQ-94-D)
Affinity DataIC50: 1.80E+4nMAssay Description:Binding affinity to PDE1B catalytic domain (1 to 516 amino acid residues) using [3H]cGMP as substrate after 15 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50034649(CHEMBL3360413)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of PDE1B2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
LigandPNGBDBM433318(US10561656, Example 1 | 3-(ethylthio)-2-(4-(5-fluo...)
Affinity DataIC50: 1.10E+4nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

LigandPNGBDBM289515(6-([1,1'-Biphenyl]-4-ylmethyl)thieno[3,2-e][1,2,4]...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandPNGBDBM289518(6-([1,1'-Biphenyl]-4-ylmethyl)-9-methylthieno[3,2-...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandPNGBDBM289526(6-([1,1'-Biphenyl]-4-ylmethyl)-8-methylthieno[3,2-...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

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