Compile Data Set for Download or QSAR
Report error Found 70 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor [1-770,'NPG',771-1210]'
LigandPNGBDBM569189(US11427559, Compound A)
Affinity DataKd: <0.5nMAssay Description:In some assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and inf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

LigandPNGBDBM557852(US11365189, Ex. No. 6 | 1-(3-((4-((3,4-dichloro-2-...)
Affinity DataIC50: 1.10nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557849(US11365189, Ex. No. 3 | 1-(3-((4-((3,4-dichlorophe...)
Affinity DataIC50: 2nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)
Affinity DataIC50: 2.30nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM731065(US20250122202, Example 115)
Affinity DataIC50: 2.46nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM731067(US20250122202, Example 104)
Affinity DataIC50: 2.72nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM730779(US20250122202, Example 60)
Affinity DataIC50: 2.82nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM731070(US20250122202, Example 109)
Affinity DataIC50: 3nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM731071(US20250122202, Example 26)
Affinity DataIC50: 3.52nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM731064(US20250122202, Example 114)
Affinity DataIC50: 4.12nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM731073(US20250122202, Example 42)
Affinity DataIC50: 4.44nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM731066(US20250122202, Example 71)
Affinity DataIC50: 4.54nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM731072(US20250122202, Example 70)
Affinity DataIC50: 6.55nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM557850(US11365189, Ex. No. 4 | 6-((1-acryloylpiperidin-4-...)
Affinity DataIC50: 7.20nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557865(US11365189, Ex. No. 25 | 1-(4-((4-((3,4-dichloro- ...)
Affinity DataIC50: 10nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557858(US11365189, Ex. No. 14 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 12nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557870(US11365189, Ex. No. 32 | 1-(3-((4-((3,4-dichloro-2...)
Affinity DataIC50: 13nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557872(US11365189, Ex. No. 37 | 1-(4-((4-((4-bromo-3- chl...)
Affinity DataIC50: 20nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557851(US11365189, Ex. No. 5 | 1-(3-((4-((2,4-dichlorophe...)
Affinity DataIC50: 23nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557868(US11365189, Ex. No. 30 | 1-(3-((4-((4-bromo-3- chl...)
Affinity DataIC50: 24nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM731069(US20250122202, Example 64)
Affinity DataIC50: 24.2nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM731068(US20250122202, Example 18)
Affinity DataIC50: 28.2nMAssay Description:The compound of the present invention had a good inhibitory activity on an EGFR kinase, and the IC50 values were all less than 10 μM. The specific ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

LigandPNGBDBM557875(US11365189, Ex. No. 41 | 1-(3-((7-methoxy-4- (phen...)
Affinity DataIC50: 29nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557898(US11365189, Ex. No. 48 | 1-(3-((4-((3,4-dichloro- ...)
Affinity DataIC50: 31nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557888(US11365189, Ex. No. 24 | 1-(3-((4-((4-bromo-3- chl...)
Affinity DataIC50: 34nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557882(US11365189, Ex. No. 17 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 70nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557846(US11365189, Ex. No. 1 | 1-(4-((4-((2,4-dichlorophe...)
Affinity DataIC50: 77nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557869(US11365189, Ex. No. 31 | 1-(3-((4-((3-cyclopropyl-...)
Affinity DataIC50: 85nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557871(US11365189, Ex. No. 35 | 1-(3-((7-methoxy-4-((4- (...)
Affinity DataIC50: 130nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557860(US11365189, Ex. No. 15 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 150nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557887(US11365189, Ex. No. 23 | 1-(4-((4-((3-chloro-4- (t...)
Affinity DataIC50: 150nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557899(US11365189, Ex. No. 51 | 1-(3-((4-((4-chloro-3- (o...)
Affinity DataIC50: 160nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557876(US11365189, Ex. No. 43 | 1-(3-((4-((3-chloro-4- (t...)
Affinity DataIC50: 170nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557854(US11365189, Ex. No. 9)
Affinity DataIC50: 190nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557880(US11365189, Ex. No. 54 | 1-(3-((4-((4-chloro-3- (h...)
Affinity DataIC50: 280nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557874(US11365189, Ex. No. 40 | 1-(3-((4-((2,4-dichloro- ...)
Affinity DataIC50: 320nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557866(US11365189, Ex. No. 27 | 1-(3-((7-methoxy-4-((3- (...)
Affinity DataIC50: 350nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557878(US11365189, Ex. No. 50 | 1-(3-((7-methoxy-4- (phen...)
Affinity DataIC50: 360nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557873(US11365189, Ex. No. 39 | 1-(4-((7-methoxy-4- (phen...)
Affinity DataIC50: 390nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557861(US11365189, Ex. No. 16 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 400nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557890(US11365189, Ex. No. 28 | 1-(4-((4-((3-cyclopropyl-...)
Affinity DataIC50: 410nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557877(US11365189, Ex. No. 49 | 1-(3-((7-methoxy-4-((3- (...)
Affinity DataIC50: 450nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557897(US11365189, Ex. No. 47 | 1-(3-((4-((4-chloro-3- (o...)
Affinity DataIC50: 550nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557894(US11365189, Ex. No. 38 | 1-(3-((4-((3-chloro-4- (t...)
Affinity DataIC50: 550nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557901(US11365189, Ex. No. 55 | 1-(3-((4-((4-chloro-3- (h...)
Affinity DataIC50: 600nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557881(US11365189, Ex. No. 99 | 1-(3-((4-((4-bromo-3- chl...)
Affinity DataIC50: 630nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557892(US11365189, Ex. No. 34 | 1-(4-((4-((4-chloro-3- (h...)
Affinity DataIC50: 660nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557867(US11365189, Ex. No. 29 | 1-(4-((7-methoxy-4-((3- (...)
Affinity DataIC50: 710nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557895(US11365189, Ex. No. 44 | 1-(3-((4-((3-cyclopropyl-...)
Affinity DataIC50: 740nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

LigandPNGBDBM557855(US11365189, Ex. No. 11 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 910nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

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