Report error Found 1225 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-2'
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.0700nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.120nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.170nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.170nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.190nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.200nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.210nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.210nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.230nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.230nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.240nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.25nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]Ro-151788 from human GABA-A receptor alpha2 subunit expressed in L(tk) cellsMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.300nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.300nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.300nMAssay Description:Binding affinity to GABA-A alpha2 (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.300nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.309nMAssay Description:Binding affinity to GABA-A alpha2 (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.310nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.370nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.380nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.390nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.400nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.410nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.430nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.440nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.460nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.480nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.5nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.560nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.570nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.580nMAssay Description:Binding affinity to GABA-A alpha2 (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.590nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.590nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.600nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: <0.600nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.610nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.650nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.650nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.660nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.670nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.680nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.700nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants
US Patent
University College Cardiff Consultants
US Patent
Affinity DataKi: 0.700nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
















































