Compile Data Set for Download or QSAR
Report error Found 1225 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-2'
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599948BDBM50599948(PHENAZEPAM)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751588BDBM751588(US20250197368, Example 100)
Affinity DataKi:  0.0700nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751601BDBM751601(US20250197368, Example 113)
Affinity DataKi:  0.120nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599949BDBM50599949(CHEMBL3274851)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751597BDBM751597(US20250197368, Example 109)
Affinity DataKi:  0.170nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751622BDBM751622(US20250197368, Example 134)
Affinity DataKi:  0.170nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751589BDBM751589(US20250197368, Example 101)
Affinity DataKi:  0.190nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751595BDBM751595(US20250197368, Example 107)
Affinity DataKi:  0.200nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751538BDBM751538(US20250197368, Example 50)
Affinity DataKi:  0.210nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751593BDBM751593(US20250197368, Example 105)
Affinity DataKi:  0.210nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751599BDBM751599(US20250197368, Example 111)
Affinity DataKi:  0.230nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751535BDBM751535(US20250197368, Example 47)
Affinity DataKi:  0.230nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751587BDBM751587(US20250197368, Example 99)
Affinity DataKi:  0.240nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751497BDBM751497(US20250197368, Example 9)
Affinity DataKi:  0.25nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 50142567BDBM50142567(9-(4-Methyl-thiazol-2-yl)-11-phenyl-6,7-dihydro-5H...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]Ro-151788 from human GABA-A receptor alpha2 subunit expressed in L(tk) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751573BDBM751573(US20250197368, Example 85)
Affinity DataKi:  0.300nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751609BDBM751609(US20250197368, Example 121)
Affinity DataKi:  0.300nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 50418481BDBM50418481(CHEMBL1783282)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to GABA-A alpha2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751619BDBM751619(US20250197368, Example 131)
Affinity DataKi:  0.300nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 50418481BDBM50418481(CHEMBL1783282)
Affinity DataKi:  0.309nMAssay Description:Binding affinity to GABA-A alpha2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751607BDBM751607(US20250197368, Example 119)
Affinity DataKi:  0.310nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751613BDBM751613(US20250197368, Example 125)
Affinity DataKi:  0.370nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751496BDBM751496(US20250197368, Example 8)
Affinity DataKi:  0.380nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751596BDBM751596(US20250197368, Example 108)
Affinity DataKi:  0.390nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751529BDBM751529(US20250197368, Example 41)
Affinity DataKi:  0.400nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751594BDBM751594(US20250197368, Example 106)
Affinity DataKi:  0.410nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751537BDBM751537(US20250197368, Example 49)
Affinity DataKi:  0.430nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751583BDBM751583(US20250197368, Example 95)
Affinity DataKi:  0.440nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751579BDBM751579(US20250197368, Example 91)
Affinity DataKi:  0.460nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751580BDBM751580(US20250197368, Example 92)
Affinity DataKi:  0.480nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751606BDBM751606(US20250197368, Example 118)
Affinity DataKi:  0.5nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751530BDBM751530(US20250197368, Example 42)
Affinity DataKi:  0.560nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751600BDBM751600(US20250197368, Example 112)
Affinity DataKi:  0.570nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 50144858BDBM50144858(3-(5-Methyl-isoxazol-3-yl)-6-(1-methyl-1H-[1,2,3]t...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to GABA-A alpha2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751495BDBM751495(US20250197368, Example 7)
Affinity DataKi:  0.590nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751598BDBM751598(US20250197368, Example 110)
Affinity DataKi:  0.590nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 50142570BDBM50142570(9-(4-Methyl-thiazol-2-yl)-11-pyridin-4-yl-6,7-dihy...)
Affinity DataKi:  0.600nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 430025BDBM430025(US10538523, Example 1 | 4-(4′-Ethanesulfonyl...)
Affinity DataKi: <0.600nMAssay Description:The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001728BDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599956BDBM50599956(CHEMBL475204)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751586BDBM751586(US20250197368, Example 98)
Affinity DataKi:  0.610nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751618BDBM751618(US20250197368, Example 130)
Affinity DataKi:  0.650nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751617BDBM751617(US20250197368, Example 129)
Affinity DataKi:  0.650nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751620BDBM751620(US20250197368, Example 132)
Affinity DataKi:  0.660nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751521BDBM751521(US20250197368, Example 33)
Affinity DataKi:  0.670nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751522BDBM751522(US20250197368, Example 34)
Affinity DataKi:  0.680nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 50179998BDBM50179998(7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...)
Affinity DataKi:  0.700nMAssay Description:Positive allosteric modulation of GABAA alpha2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandChemical structure of BindingDB Monomer ID 247432BDBM247432(US9453021, 39)
Affinity DataIC50: 0.700nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandChemical structure of BindingDB Monomer ID 751623BDBM751623(US20250197368, Example 135)
Affinity DataKi:  0.700nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599952BDBM50599952(CHEMBL3246832)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
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