Compile Data Set for Download or QSAR
Report error Found 1281 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-5'
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133600(US8846719, 311)
Affinity DataKi:  0.100nM ΔG°:  -53.1kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133597(US8846719, 308)
Affinity DataKi:  0.200nM ΔG°:  -51.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50599949(CHEMBL3274851)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha5beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM755028(3-[7-chloro-8-(trifluoromethyl)-4H-[1,2,4]triazolo...)
Affinity DataKi:  0.270nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10517(US8846719, 302)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10467(US8846719, 294)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10521(US8846719, 303)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50610205(CHEMBL5268764)
Affinity DataKi:  0.300nMAssay Description:Displacement of flumazenil from alpha5 GABAA receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10673(US8846719, 289)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133596(US8846719, 306)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10484(US8846719, 301 | US11091471, Example RO-301 | US20...)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM756794(3-(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl) m...)
Affinity DataKi:  0.320nMAssay Description:The assay was carried out in a 200 μL system (96-well plate from Agilent) with 100 μL of cell membrane. The concentration of 3H-flunitazepam (from Pe...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent

LigandPNGBDBM719133(6,7-dichloro-5-(2-fluoro-5-hydroxy-phenyl)-1-methy...)
Affinity DataKi:  0.340nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM719133(6,7-dichloro-5-(2-fluoro-5-hydroxy-phenyl)-1-methy...)
Affinity DataKi:  0.340nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

LigandPNGBDBM755021(3-(7,8-dichloro-1-methyl-4H-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi:  0.360nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM755022(4-fluoro-3-[(4S)-7,8-dichloro-1,4-dimethyl-4H-[1,2...)
Affinity DataKi:  0.380nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM755024(8,9-dichloro-7-(2-fluoro-5-hydroxy-phenyl)-5H-pyri...)
Affinity DataKi:  0.390nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM755023((5S)-8,9-dichloro-7-(2-fluoro-5-hydroxy-phenyl)-5-...)
Affinity DataKi:  0.390nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10711(US8846719, 292)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50599953(CHEMBL1451229)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha5beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133578(US8846719, 270)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

LigandPNGBDBM755031(3-(7,8-dichloro-1-methyl-4H-[1,2,4]triazolo[4,3-a]...)
Affinity DataKi:  0.400nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133599(US8846719, 310)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10468(US8846719, 295)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

LigandPNGBDBM759197((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  0.400nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50049736(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to GABAA alpha-5-beta-3-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10672(US8846719, 288)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

LigandPNGBDBM755026(6-chloro-5-(2-fluoro-5-hydroxy-phenyl)-1-methyl-7-...)
Affinity DataKi:  0.440nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50067424((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...)
Affinity DataKi:  0.450nMAssay Description:Positive allosteric modulation of GABAA alpha5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM759206([7,8-dichloro-6-(2,6-difluorophenyl)-4H-[1,2,4]tri...)
Affinity DataKi:  0.450nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM755030(6,7-dichloro-5-(2,6-difluoro-3-hydroxy-phenyl)-1-m...)
Affinity DataKi:  0.460nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM25877(CHEMBL286594 | ethyl 12-ethynyl-8-methyl-9-oxo-2,4...)
Affinity DataKi:  0.490nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133565(US8846719, 257)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133594(US8846719, 299)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10667(US8846719, 284)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50144861(3-(5-Methyl-isoxazol-3-yl)-6-(pyridin-2-ylmethoxy)...)
Affinity DataKi:  0.5nMAssay Description:Negative allosteric modulation of alpha5 GABAA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM643722((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  0.5nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM50244073(ethyl 7-fluoro-4-methyl-5-oxo-1,3a,4,5-tetrahydroi...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133568(US8846719, 260)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

LigandPNGBDBM759247((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  0.5nMAssay Description:Table 1 and 3: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]Fluma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM10483(US8846719, 297)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

LigandPNGBDBM719134(6-chloro-5-(2-fluoro-5-hydroxy-phenyl)-1,7-dimethy...)
Affinity DataKi:  0.530nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM719134(6-chloro-5-(2-fluoro-5-hydroxy-phenyl)-1,7-dimethy...)
Affinity DataKi:  0.530nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM756798(4-(((6-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazo...)
Affinity DataKi:  0.540nMAssay Description:The assay was carried out in a 200 μL system (96-well plate from Agilent) with 100 μL of cell membrane. The concentration of 3H-flunitazepam (from Pe...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50599952(CHEMBL3246832)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha5beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Rat)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049736(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of [3H]flunitrazepam binding to high affinity GABA-A receptor of rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133595(US8846719, 298)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133542(US8846719, 234)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50599957(CHEMBL5179977)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha5beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Roche Palo Alto

US Patent
LigandPNGBDBM133598(US8846719, 309)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

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