Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-3 [26-473]/gamma-2 [40-467]'
LigandPNGBDBM25877(CHEMBL286594 | ethyl 12-ethynyl-8-methyl-9-oxo-2,4...)
Affinity DataKi:  0.490nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
LigandPNGBDBM649937(1-(6-{[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl...)
Affinity DataKi:  0.900nMAssay Description:Receptor binding assays were performed in 96-well format in deep-well plates. For each 96-well plate one ampulle of membrane homogenate was thawed an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

LigandPNGBDBM25880(5-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...)
Affinity DataKi:  5.40nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
LigandPNGBDBM649918(1-(6-{[1-(4-fluorophenyl)-4-methyl-1H-1,2,3-triazo...)
Affinity DataKi:  10nMAssay Description:Receptor binding assays were performed in 96-well format in deep-well plates. For each 96-well plate one ampulle of membrane homogenate was thawed an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

LigandPNGBDBM25883(ethyl 12-ethynyl-9-phenyl-2,4,8-triazatricyclo[8.4...)
Affinity DataKi:  13.8nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
LigandPNGBDBM25879(CHEMBL35571 | 3-({12-ethynyl-8-methyl-9-oxo-2,4,8-...)
Affinity DataKi:  15nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
LigandPNGBDBM649920(1-(6-{[4-(4-fluorophenyl)-1-methyl-1H-1,2,3-triazo...)
Affinity DataKi:  32nMAssay Description:Receptor binding assays were performed in 96-well format in deep-well plates. For each 96-well plate one ampulle of membrane homogenate was thawed an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

LigandPNGBDBM25882([({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo[...)
Affinity DataKi:  76.1nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
LigandPNGBDBM25881(3-({12-ethyl-8-methyl-9-oxo-2,4,8-triazatricyclo[8...)
Affinity DataKi:  101nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
LigandPNGBDBM25885(3-({12-ethynyl-9-phenyl-2,4,8-triazatricyclo[8.4.0...)
Affinity DataKi:  194nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
LigandPNGBDBM25884(2-[2-({12-ethynyl-9-phenyl-2,4,8-triazatricyclo[8....)
Affinity DataKi:  5.00E+3nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed