Report error Found 291 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 2C'
Affinity DataKi: 6nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Ability to displace [3H]TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Ability to displace [3H]TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Ability to displace [3H]TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 34nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
Affinity DataKi: 56nMAssay Description:Ability to displace [3H]TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Binding affinity against phencyclidine receptor was determined by the displacement of [3H]TCP of whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 81nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 91nMAssay Description:Binding affinity of compound against Phencyclidine receptor by displacement of [3H]TCPMore data for this Ligand-Target Pair
Affinity DataKi: 92nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2B NMDA expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB N-methyl-D-aspartate (NMDA) expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 111nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
Affinity DataKi: 114nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Binding affinity against phencyclidine receptor was determined by the displacement of [3H]TCP of whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB N-methyl-D-aspartate (NMDA) expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Compound was evaluated for in vitro inhibition of [3H]L-689,560 at NMDA receptor.More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 231nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
Affinity DataKi: 231nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 263nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
Affinity DataKi: 281nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 324nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 370nMAssay Description:Binding affinity of compound was tested on Phencyclidine binding assay.More data for this Ligand-Target Pair
Affinity DataKi: 370nMAssay Description:Inhibitory activity against sigma receptor isolated from guinea pig brain cortex membrane using PCP as radioligand at a concentration of 10e-5 MMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Compound was evaluated for in vitro inhibition of cortical slice release at NMDA receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Compound was evaluated for in vitro inhibition of [3H]-GABA release at NMDA receptor.More data for this Ligand-Target Pair
Affinity DataKi: 422nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 530nMAssay Description:Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047More data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition activity against binding of phencyclidine receptor was determined by the displacement of [3H]-TCP of whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
Affinity DataKi: 601nMAssay Description:Ability to displace [3H]TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Concentration required for 50% Inhibition of responses at cloned NR1A/2AB N-methyl-D-aspartate (NMDA) expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Binding affinity of compound against Phencyclidine receptor by displacement of [3H]TCPMore data for this Ligand-Target Pair
Affinity DataKi: 650nMAssay Description:Compound was evaluated for in vitro inhibition of cortical neuron at NMDA receptorMore data for this Ligand-Target Pair
Affinity DataKi: 680nMAssay Description:Binding affinity to sigma site of Phencyclidine receptor by displacement of [3H]-(+)-SKF- 10,047More data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Compound with the N-methyl-D-aspartate glutamate receptor blocking activityMore data for this Ligand-Target Pair
Affinity DataIC50: 710nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataKi: 733nMAssay Description:Ability to displace [3H]TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
Affinity DataKi: 750nMAssay Description:Compound was evaluated for in vitro inhibition of cortical neuron at NMDA receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 770nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 780nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 780nMAssay Description:Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair






3D Structure (crystal)




































