Compile Data Set for Download or QSAR
Report error Found 3594 Enz. Inhib. hit(s) with Target = 'Glutaminase kidney isoform, mitochondrial'
LigandPNGBDBM50503299(CHEMBL4538736)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of kidney-type glutaminase in human BT20 cells assessed as reduction in glutamate levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503300(CHEMBL4547874)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of kidney-type glutaminase in human BT20 cells assessed as reduction in glutamate levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50172241(CHEMBL3810168 | US10294221, Example 22(a))
Affinity DataIC50: 0.206nMAssay Description:Inhibition of GLS1 in human PC3 cells assessed as cellular glutamate depletion levels after 6 hrs by Glutamate Oxidase/ AmplexRed coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50172181(CHEMBL3810394 | US10040788, Example 3 | US10294221...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of GLS1 in human PC3 cells assessed as cellular glutamate depletion levels after 6 hrs by Glutamate Oxidase/ AmplexRed coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50172239(CHEMBL3809014 | US10040788, Example 11 | US1029422...)
Affinity DataIC50: 0.401nMAssay Description:Inhibition of GLS1 in human PC3 cells assessed as cellular glutamate depletion levels after 6 hrs by Glutamate Oxidase/ AmplexRed coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50503313(CHEMBL4454263)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of kidney-type glutaminase in human BT20 cells assessed as reduction in glutamate levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50517275(CHEMBL4469040)
Affinity DataIC50: 1nMAssay Description:Inhibition of human KGA preincubated for 15 to 30 mins followed by substrate addition and measured after 3 to 4 hrs by GDH-EZMTT reagent-based GDH co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50517268(CHEMBL4475144)
Affinity DataIC50: 1nMAssay Description:Inhibition of human KGA preincubated for 15 to 30 mins followed by substrate addition and measured after 3 to 4 hrs by GDH-EZMTT reagent-based GDH co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM109086(US8604016, 670 | US9938267, Cmpd ID 670 | US107935...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to wild type human KGA assessed as covalent bond formation by measuring dissociation constant by biomolecular interaction assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM108895(US8604016, 475 | US9938267, Cmpd ID 475)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108853(US8604016, 433 | US9938267, Cmpd ID 433)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108787(US8604016, 367 | US9938267, Cmpd ID 367)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108852(US8604016, 432 | US9938267, Cmpd ID 432)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM47230(US8604016, 645 | US9938267, Cmpd ID 645)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108855(US8604016, 435 | US9938267, Cmpd ID 435)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108855(US8604016, 435 | US9938267, Cmpd ID 435)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM47230(US8604016, 645 | US9938267, Cmpd ID 645)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108893(US8604016, 473 | US9938267, Cmpd ID 473)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108893(US8604016, 473 | US9938267, Cmpd ID 473)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM109086(US8604016, 670 | US9938267, Cmpd ID 670 | US107935...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human KGA preincubated for 15 to 30 mins followed by substrate addition and measured after 3 to 4 hrs by GDH-EZMTT reagent-based GDH co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM108895(US8604016, 475 | US9938267, Cmpd ID 475)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108853(US8604016, 433 | US9938267, Cmpd ID 433)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108852(US8604016, 432 | US9938267, Cmpd ID 432)
Affinity DataIC50: 2nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM109086(US8604016, 670 | US9938267, Cmpd ID 670 | US107935...)
Affinity DataIC50: 2nMAssay Description:Negative allosteric modulator activity at human wildtype KGA incubated for 5 hrs in presence of GDH and NADP by EZMTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50503298(CHEMBL4462146)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of kidney-type glutaminase in human BT20 cells assessed as reduction in glutamate levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM108864(US8604016, 444 | US9938267, Cmpd ID 444)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108994(US8604016, 576 | US9938267, Cmpd ID 576)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM387316(US9938267, Cmpd ID 644)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108990(US8604016, 572 | US9938267, Cmpd ID 572)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108891(US8604016, 471 | US9938267, Cmpd ID 471)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108890(US8604016, 470 | US9938267, Cmpd ID 470)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108894(US8604016, 474 | US9938267, Cmpd ID 474)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108873(US8604016, 453 | US9938267, Cmpd ID 453)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM387200(US9938267, Cmpd ID 517)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108804(US8604016, 384 | US9938267, Cmpd ID 384)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM387199(US9938267, Cmpd ID 516)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108903(US8604016, 484 | US9938267, Cmpd ID 484)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108802(US8604016, 382 | US9938267, Cmpd ID 382)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108871(US8604016, 451 | US9938267, Cmpd ID 451)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108878(US8604016, 458 | US9938267, Cmpd ID 458)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108876(US8604016, 456 | US9938267, Cmpd ID 456)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108875(US8604016, 455 | US9938267, Cmpd ID 455)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108980(US8604016, 561 | US9938267, Cmpd ID 562)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM109041(US8604016, 623)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108917(US8604016, 498 | US9938267, Cmpd ID 498)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108915(US8604016, 496 | US9938267, Cmpd ID 496)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108978(US8604016, 560 | US9938267, Cmpd ID 560 | BDBM1089...)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

LigandPNGBDBM108890(US8604016, 470 | US9938267, Cmpd ID 470)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM108894(US8604016, 474 | US9938267, Cmpd ID 474)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
US Patent

LigandPNGBDBM109060(US8604016, 644)
Affinity DataIC50: 3nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

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