Report error Found 634 Enz. Inhib. hit(s) with Target = 'Hematopoietic prostaglandin D synthase'
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataKd: 0.140nMAssay Description:Binding affinity to full length recombinant human N-terminal His6-tagged H-PGDS expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HPGDSMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataKd: 0.240nMAssay Description:Binding affinity to human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as equilibrium dissociation constant by measuring changes in i...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataKd: 0.370nMAssay Description:Binding affinity to full length recombinant human N-terminal His6-tagged H-PGDS expressed in Escherichia coli BL21(DE3) by SPR analysisMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataKd: 0.5nMAssay Description:Binding affinity to full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assayMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 2.34nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
Affinity DataEC50: <2.5nMAssay Description:Inhibition of H-PGDS in rat RBL cells assessed as reduction in A23187-induced PGD2 production pretreated for 30 mins followed by A23187 addition for ...More data for this Ligand-Target Pair
Affinity DataEC50: <2.5nMAssay Description:Inhibition of H-PGDS in rat RBL cells assessed as reduction in A23187-induced PGD2 production pretreated for 30 mins followed by A23187 addition for ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:The H-PGDS binding inhibitory activity of the test compound was measured by AlphaLISA antagonistic assay. A specific protocol is as follows. In an A...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:The H-PGDS binding inhibitory activity of the test compound was measured by AlphaLISA antagonistic assay. A specific protocol is as follows. In an A...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:The H-PGDS binding inhibitory activity of the test compound was measured by AlphaLISA antagonistic assay. A specific protocol is as follows. In an A...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:The H-PGDS binding inhibitory activity of the test compound was measured by AlphaLISA antagonistic assay. A specific protocol is as follows. In an A...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
Affinity DataEC50: 3.70nMAssay Description:Inhibition of H-PGDS in rat RBL cells assessed as reduction in A23187-induced PGD2 production pretreated for 30 mins followed by A23187 addition for ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
Affinity DataEC50: 3.80nMAssay Description:Inhibition of H-PGDS in rat RBL cells assessed as reduction in A23187-induced PGD2 production pretreated for 30 mins followed by A23187 addition for ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
Affinity DataEC50: 3.90nMAssay Description:Inhibition of H-PGDS in rat RBL cells assessed as reduction in A23187-induced PGD2 production pretreated for 30 mins followed by A23187 addition for ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.90nMAssay Description:Inhibition of H-PGDS in rat RBL cells assessed as reduction in A23187-induced PGD2 production pretreated for 30 mins followed by A23187 addition for ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 4nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:The H-PGDS binding inhibitory activity of the test compound was measured by AlphaLISA antagonistic assay. A specific protocol is as follows. In an A...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
Affinity DataEC50: 4.70nMAssay Description:Inhibition of H-PGDS in rat RBL cells assessed as reduction in A23187-induced PGD2 production pretreated for 30 mins followed by A23187 addition for ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:The H-PGDS binding inhibitory activity of the test compound was measured by AlphaLISA antagonistic assay. A specific protocol is as follows. In an A...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:The H-PGDS binding inhibitory activity of the test compound was measured by AlphaLISA antagonistic assay. A specific protocol is as follows. In an A...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
Affinity DataEC50: 5.20nMAssay Description:Inhibition of H-PGDS in rat RBL cells assessed as reduction in A23187-induced PGD2 production pretreated for 30 mins followed by A23187 addition for ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 5.90nMAssay Description:Inhibition of HPGDS (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human HPGDS assessed as reduction in PGD2 formation using PGH2 as substrate by mass spectrometryMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 6nMpH: 8.0 T: 2°CAssay Description:The assay is carried out by the following steps: 1. Inhibitor screening is performed in 100 mM Tris-HCl, pH 8.0 containing 1 mM GSH, 1 mM MgCl.sub.2,...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE3 cells assessed as reduction in PGD2 production using PGH2 as substrate by RapidFire...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Human)
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Riken Center For Biosystems Dynamics Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:The H-PGDS binding inhibitory activity of the test compound was measured by AlphaLISA antagonistic assay. A specific protocol is as follows. In an A...More data for this Ligand-Target Pair



3D Structure (crystal)





































