Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor [G595R]'
TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515354(US11098060, Example 34 | US11098060, Example 12)
Affinity DataIC50: 0.340nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515356(US11098060, Example 14 | (13E,14E,22R,24S)-12-amin...)
Affinity DataIC50: 0.400nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM775591(US12435089, Example 69)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM775590(US12435089, Example 68)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515357(US11098060, Example 15 | (13E,14E,22R,24S,5S)-12-a...)
Affinity DataIC50: 0.530nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515367(US11098060, Example 26)
Affinity DataIC50: 0.680nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515368(US11098060, Example 27 | (13E,14E,22R,24S)-12-amin...)
Affinity DataIC50: 0.680nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM774115( WO2019210835, Example 5 | US12428433, Positive co...)
Affinity DataIC50: 0.720nMAssay Description:Inhibitory activities of the compound of the present application on three kinases TRKa, TRKA(G595R) and TRKC(G623R) were measured.2. Experimental Mat...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515361(US11098060, Example 19 | (13E,14E,22R,24S,6R)-12-a...)
Affinity DataIC50: 0.730nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515358(US11098060, Example 16 | (13E,14E,22R,24S)-12-amin...)
Affinity DataIC50: 0.760nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515351(US11098060, Example 9 | (13E,14E,22R,24R)-12-amino...)
Affinity DataIC50: 0.840nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515363(US11098060, Example 21)
Affinity DataIC50: 0.850nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM774116(US12428433, Example 3)
Affinity DataIC50: 0.890nMAssay Description:Inhibitory activities of the compound of the present application on three kinases TRKa, TRKA(G595R) and TRKC(G623R) were measured.2. Experimental Mat...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM774117(WO2019210835, Example 6 | US12428433, Positive con...)
Affinity DataIC50: 0.970nMAssay Description:Inhibitory activities of the compound of the present application on three kinases TRKa, TRKA(G595R) and TRKC(G623R) were measured.2. Experimental Mat...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765372(((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765348(US12391687, Example 19)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765370(2-(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrro...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765342(US12391687, Example 13)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765371(2-(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrro...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765351(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolid...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765353(US12391687, Example 24)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765349(US12391687, Example 20)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765350(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolid...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765366(2-(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrro...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765364(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolid...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765365(5-(1-(2,2-difluoroethyl)-1H-pyrazol-3-yl)-3-((2R,4...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765362(US12391687, Example 33)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765356(US12391687, Example 27)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765357(US12391687, Example 28)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765354(US12391687, Example 25)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765355(US12391687, Example 26)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765361(1-(4-(3-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropy...)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM765359(US12391687, Example 30)
Affinity DataIC50: 1nMAssay Description:Table 3: Experimental MaterialsThe recombinant human TRKA (G595R), TRKA (G667C) and TRKC (G623R) proteins were purchased from SignalChem. HTRF kinEAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/25/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515369(US11098060, Example 28 | (13E,14E,22R,6R)-12-amino...)
Affinity DataIC50: 1.01nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515359(US11098060, Example 17 | (13E,14E,22R,24S)-12-amin...)
Affinity DataIC50: 1.05nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515370(US11098060, Example 29 | (13E,14E,22R,24S,6S)-12-a...)
Affinity DataIC50: 1.08nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM774114(US12428433, Example 2)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activities of the compound of the present application on three kinases TRKa, TRKA(G595R) and TRKC(G623R) were measured.2. Experimental Mat...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515360(US11098060, Example 18 | (13E,14E,22R,24S)-12-amin...)
Affinity DataIC50: 1.24nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515372(US11098060, Example 32 | (13E,14E,22R,5S)-12-amino...)
Affinity DataIC50: 1.28nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515375(US11098060, Example 35 | (13E,14E,22R,24S)-12-amin...)
Affinity DataIC50: 1.36nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515365(US11098060, Example 23)
Affinity DataIC50: 1.40nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515371(US11098060, Example 31 | (13E,14E,22R,24S)-12-amin...)
Affinity DataIC50: 1.45nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 1.60nMAssay Description:Inhibitory activities of the compound of the present application on three kinases TRKa, TRKA(G595R) and TRKC(G623R) were measured.2. Experimental Mat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515352(US11098060, Example 10 | (R,13E,14E)-12-amino-35-f...)
Affinity DataIC50: 1.92nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM769500((3R,11R)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,...)
Affinity DataIC50: 2.03nMAssay Description:Table 1: The experimental methods were operated according to the steps in the kit instruction, and were briefly described as follows: a test compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM515350(US11098060, Example 8 | (R,13E,14E)-12-amino-35-fl...)
Affinity DataIC50: 2.08nMAssay Description:TrkAG595R (Kinase domain) kinase was expressed in Sf9 cells using pIEX-Bac-4, and purified by using affinity chromatography on AKTA Purifier (GE comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM774109(US12428433, Example 1)
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activities of the compound of the present application on three kinases TRKa, TRKA(G595R) and TRKC(G623R) were measured.2. Experimental Mat...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM769499((2R,14R)-19-fluoro-2-methyl-16,22-dioxa-3,5,7,8,12...)
Affinity DataIC50: 2.65nMAssay Description:Table 1: The experimental methods were operated according to the steps in the kit instruction, and were briefly described as follows: a test compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM775572(US12435089, Example 28)
Affinity DataIC50: 2.75nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM775592(US12435089, Example 71)
Affinity DataIC50: 2.75nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

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